C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast activation protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000392 Fap 10090 - 2:62500943-62574075 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000402 Fap-008 62501184-62573851 protein_coding
  ENSMUST00000102732 Fap-001 62500943-62574075 protein_coding
  ENSMUST00000128139 Fap-007 62501123-62503424 nonsense_mediated_decay
  ENSMUST00000136297 Fap-003 62535783-62573923 retained_intron
  ENSMUST00000152085 Fap-004 62501113-62573980 processed_transcript
  ENSMUST00000172676 Fap-002 62527349-62563717 retained_intron
  ENSMUST00000173745 Fap-005 62548584-62573560 protein_coding
  ENSMUST00000174234 Fap-006 62501184-62573851 protein_coding
  ENSMUST00000174448 Fap-009 62501184-62573851 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000402ENSMUST00000102732ENSMUST00000128139ENSMUST00000136297ENSMUST00000152085ENSMUST00000172676ENSMUST00000173745ENSMUST00000174234ENSMUST00000174448
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000402 N/A 0.133±0.04 N/A N/A N/A 0.213±0.00 N/A N/A 0.043±0.00 N/A N/A 0.406±0.19 N/A 0.025±0.02
ENSMUST00000102732 1.834±0.19 0.168±0.00 0.269±0.00 0.227±0.17 4.102±1.76 0.427±0.14 0.692±0.16 0.143±0.02 0.061±0.03 0.149±0.05 0.380±0.04 0.425±0.20 0.265±0.23 0.017±0.00
ENSMUST00000128139 N/A 0.551±0.34 N/A 5.610±0.00 N/A N/A N/A 0.142±0.06 0.262±0.10 N/A N/A 1.543±0.99 0.974±0.89 N/A
ENSMUST00000136297 N/A 0.158±0.00 N/A N/A N/A 0.289±0.00 N/A 0.033±0.00 0.041±0.00 0.073±0.00 N/A 0.300±0.12 0.008±0.00 N/A
ENSMUST00000152085 1.031±0.18 0.239±0.08 N/A 0.619±0.35 3.720±1.82 0.226±0.00 0.781±0.19 0.115±0.05 0.102±0.08 0.142±0.07 0.506±0.12 0.769±0.16 0.448±0.25 N/A
ENSMUST00000172676 N/A 0.113±0.02 N/A N/A N/A 0.127±0.04 N/A 0.050±0.02 0.030±0.00 0.058±0.00 N/A N/A N/A N/A
ENSMUST00000173745 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.045±0.00 N/A
ENSMUST00000174234 N/A 0.063±0.00 N/A N/A N/A 0.165±0.00 N/A 0.060±0.00 0.035±0.00 N/A N/A 0.067±0.00 0.014±0.00 N/A
ENSMUST00000174448 N/A 0.191±0.00 N/A N/A 2.026±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003S0 CIL_0003S0_0003 CGP 2:62474530-62574075
CIL_0005KX CIL_0005KX_0002 CGP 2:62500943-62646255

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IEA protease binding
GO:0004175 IEA endopeptidase activity
GO:0004252 ISS serine-type endopeptidase activity
GO:0005178 IEA integrin binding
GO:0005515 IEA protein binding
GO:0005615 IEA extracellular space
GO:0005886 ISS plasma membrane
GO:0005925 IEA focal adhesion
GO:0006508 IEA:ISS proteolysis
GO:0008233 IDA peptidase activity
GO:0008236 ISS serine-type peptidase activity
GO:0008239 ISS dipeptidyl-peptidase activity
GO:0009986 IDA cell surface
GO:0010710 ISS regulation of collagen catabolic process
GO:0010716 ISS negative regulation of extracellular matrix disassembly
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0030027 ISS lamellipodium
GO:0030054 IEA cell junction
GO:0042803 ISS protein homodimerization activity
GO:0043542 ISS endothelial cell migration
GO:0045177 IDA apical part of cell
GO:0045178 IDA basal part of cell
GO:0051603 ISS proteolysis involved in cellular protein catabolic process
GO:0060244 IDA negative regulation of cell proliferation involved in contact inhibition
GO:0071158 IDA positive regulation of cell cycle arrest
GO:0071438 ISS invadopodium membrane
GO:0071850 IDA mitotic cell cycle arrest
GO:0097325 IDA melanocyte proliferation
GO:1900119 IDA positive regulation of execution phase of apoptosis
GO:1902362 IDA melanocyte apoptotic process
GO:1903054 ISS negative regulation of extracellular matrix organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078468 fap fibroblast activation protein, alpha protein_coding Danio_rerio
ENSDARG00000079420 dpp4 dipeptidyl-peptidase 4 protein_coding Danio_rerio
ENSG00000078098 FAP fibroblast activation protein, alpha protein_coding Homo_sapiens

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