C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: fibroblast activation protein, alpha
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000188790 FAP-001 ENSG00000078098 9606 - 2:162170690-162243535 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBreastColonHeartKidneyLungOvaryPlacentaTestisENST00000188790
Transcript ID Adipose Breast Colon Heart Kidney Lung Ovary Placenta Testis
ENST00000188790 2.507±0.00 4.183±2.57 0.963±0.76 0.140±0.00 0.475±0.00 1.015±0.00 0.968±0.48 2.628±0.08 2.038±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003S0 CIL_0003S0_0002 CGP 2:162142873-162245151
CIL_0005KX CIL_0005KX_0001 CGP 2:162170684-162318703

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002020 IPI protease binding
GO:0004175 IDA endopeptidase activity
GO:0004222 TAS metalloendopeptidase activity
GO:0004252 IDA serine-type endopeptidase activity
GO:0005178 IPI integrin binding
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005886 NAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0006508 IEA:IDA proteolysis
GO:0008233 IDA peptidase activity
GO:0008236 IDA:IEA serine-type peptidase activity
GO:0008239 IDA dipeptidyl-peptidase activity
GO:0009986 ISS cell surface
GO:0010710 IDA regulation of collagen catabolic process
GO:0010716 IDA negative regulation of extracellular matrix disassembly
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0030027 IDA lamellipodium
GO:0032587 NAS ruffle membrane
GO:0042803 IDA protein homodimerization activity
GO:0043542 IDA endothelial cell migration
GO:0045177 IEA apical part of cell
GO:0045178 IEA basal part of cell
GO:0046983 NAS protein dimerization activity
GO:0051603 IDA proteolysis involved in cellular protein catabolic process
GO:0051917 IC regulation of fibrinolysis
GO:0060244 ISS negative regulation of cell proliferation involved in contact inhibition
GO:0071158 ISS positive regulation of cell cycle arrest
GO:0071438 IDA invadopodium membrane
GO:0071850 ISS mitotic cell cycle arrest
GO:0097325 ISS melanocyte proliferation
GO:1900119 ISS positive regulation of execution phase of apoptosis
GO:1902362 ISS melanocyte apoptotic process
GO:1903054 IDA negative regulation of extracellular matrix organization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000102732 Fap-001 protein_coding Mus_musculus 0 3085
ENSMUST00000174448 Fap-009 protein_coding Mus_musculus 0 2822
ENSMUST00000000402 Fap-008 protein_coding Mus_musculus 0 2710
ENSMUST00000174234 Fap-006 protein_coding Mus_musculus 0 2488
ENSMUST00000172676 Fap-002 retained_intron Mus_musculus 0 1714
ENSMUST00000152085 Fap-004 processed_transcript Mus_musculus 0 1375
ENSMUST00000136297 Fap-003 retained_intron Mus_musculus 0 1267
ENSMUST00000128139 Fap-007 nonsense_mediated_decay Mus_musculus 0 206

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