C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: itchy E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000078747 ITCH 9606 + 20:34363235-34511393 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262650 ITCH-002 34363312-34508035 protein_coding
  ENST00000374864 ITCH-001 34363235-34511393 protein_coding
  ENST00000461661 ITCH-007 34471501-34481182 processed_transcript
  ENST00000479215 ITCH-004 34363295-34369543 processed_transcript
  ENST00000483727 ITCH-005 34445361-34481176 processed_transcript
  ENST00000486883 ITCH-003 34363241-34413879 processed_transcript
  ENST00000535650 ITCH-201 34393768-34511392 protein_coding
  ENST00000610336 ITCH-202 34393768-34511392 protein_coding
  ENST00000621101 ITCH-203 34393768-34511392 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262650ENST00000374864ENST00000486883ENST00000535650ENST00000610336
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262650 2.696±0.00 N/A 2.822±0.00 2.658±0.09 7.589±0.00 9.205±0.00 2.064±0.60 4.691±0.00 5.925±0.00 5.876±0.00 2.013±0.00 4.501±1.36 3.706±0.00 10.594±3.26
ENST00000374864 4.047±0.00 N/A 2.077±0.00 2.945±0.00 3.928±2.41 2.022±0.00 0.905±0.20 6.923±0.00 2.431±0.20 N/A 0.419±0.00 2.300±1.04 1.916±0.51 3.603±0.00
ENST00000486883 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.714±0.00 N/A N/A N/A
ENST00000535650 N/A 1.921±0.00 N/A 1.275±0.00 N/A N/A 1.039±0.00 N/A N/A N/A N/A 1.719±0.00 N/A 2.417±0.00
ENST00000610336 2.628±0.00 1.294±0.00 N/A N/A 3.662±0.00 2.380±0.75 3.756±0.00 N/A N/A N/A 6.849±0.00 4.853±1.28 2.326±0.81 2.778±1.71

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098F CIL_00098F_0001 VISTA 20:33968769-34569610
CIL_0003SW CIL_0003SW_0001 CGP 20:34280268-34511393
CIL_0005BA CIL_0005BA_0001 CGP 20:34363235-34540958

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IEA protein polyubiquitination
GO:0001558 NAS regulation of cell growth
GO:0002669 IEA positive regulation of T cell anergy
GO:0004842 NAS:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005938 IEA cell cortex
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006915 IEA apoptotic process
GO:0006954 NAS inflammatory response
GO:0007219 TAS Notch signaling pathway
GO:0016020 IDA membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0031410 IEA cytoplasmic vesicle
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032480 TAS negative regulation of type I interferon production
GO:0035519 IDA protein K29-linked ubiquitination
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043021 IPI ribonucleoprotein complex binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045236 IPI CXCR chemokine receptor binding
GO:0045732 IEA positive regulation of protein catabolic process
GO:0046329 ISS negative regulation of JNK cascade
GO:0046642 IEA negative regulation of alpha-beta T cell proliferation
GO:0046718 TAS viral entry into host cell
GO:0050687 IMP negative regulation of defense response to virus
GO:0051607 IEA defense response to virus
GO:0070062 IDA extracellular vesicular exosome
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 IDA protein K63-linked ubiquitination
GO:0070936 IDA protein K48-linked ubiquitination
GO:0090085 ISS regulation of protein deubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074903 itcha itchy E3 ubiquitin protein ligase a protein_coding Danio_rerio
ENSDARG00000076149 ITCH (2 of 2) itchy E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSMUSG00000027598 Itch itchy, E3 ubiquitin protein ligase protein_coding Mus_musculus

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