C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: itchy, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027598 Itch 10090 + 2:155133509-155226855 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029126 Itch-001 155133509-155226855 protein_coding
  ENSMUST00000109685 Itch-002 155133559-155226853 protein_coding
  ENSMUST00000123497 Itch-004 155133561-155212594 retained_intron
  ENSMUST00000126648 Itch-007 155133509-155139289 retained_intron
  ENSMUST00000138468 Itch-005 155133524-155177147 retained_intron
  ENSMUST00000142147 Itch-003 155133531-155202710 processed_transcript
  ENSMUST00000155360 Itch-006 155133509-155174289 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029126ENSMUST00000109685ENSMUST00000138468ENSMUST00000142147ENSMUST00000155360
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029126 3.692±1.46 1.549±1.16 6.033±2.81 6.499±0.53 2.135±0.47 4.049±1.38 2.762±0.89 5.748±2.39 4.242±1.56 5.510±1.90 3.475±0.32 5.819±3.76 6.755±2.46 2.628±0.68
ENSMUST00000109685 N/A 0.909±0.00 1.160±0.00 1.794±0.47 N/A N/A N/A N/A 0.760±0.12 N/A 0.791±0.21 1.274±0.43 2.109±1.07 0.873±0.40
ENSMUST00000138468 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.078±0.00 N/A N/A
ENSMUST00000142147 N/A N/A N/A 7.774±0.00 N/A N/A N/A N/A N/A N/A N/A 11.007±0.00 9.395±4.05 N/A
ENSMUST00000155360 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 7.904±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098F CIL_00098F_0002 VISTA 2:154750090-155352094
CIL_0003SW CIL_0003SW_0002 CGP 2:155059310-155226855
CIL_0005BA CIL_0005BA_0002 CGP 2:155133509-155250277

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 ISA ubiquitin ligase complex
GO:0000209 IDA protein polyubiquitination
GO:0002669 IMP positive regulation of T cell anergy
GO:0004842 ISS ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0005938 IDA cell cortex
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006915 IEA apoptotic process
GO:0016020 IDA membrane
GO:0016567 ISS protein ubiquitination
GO:0016874 IMP ligase activity
GO:0031410 IDA cytoplasmic vesicle
GO:0032088 IMP negative regulation of NF-kappaB transcription factor activity
GO:0035519 ISS protein K29-linked ubiquitination
GO:0042787 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043021 IEA ribonucleoprotein complex binding
GO:0043066 ISS negative regulation of apoptotic process
GO:0045087 IEA innate immune response
GO:0045236 IEA CXCR chemokine receptor binding
GO:0045732 IDA positive regulation of protein catabolic process
GO:0046329 IMP negative regulation of JNK cascade
GO:0046642 IMP negative regulation of alpha-beta T cell proliferation
GO:0050687 IMP negative regulation of defense response to virus
GO:0051607 IEA defense response to virus
GO:0070062 IEA extracellular vesicular exosome
GO:0070534 ISS protein K63-linked ubiquitination
GO:0070936 ISS protein K48-linked ubiquitination
GO:0090085 IMP regulation of protein deubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074903 itcha itchy E3 ubiquitin protein ligase a protein_coding Danio_rerio
ENSDARG00000076149 ITCH (2 of 2) itchy E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSG00000078747 ITCH itchy E3 ubiquitin protein ligase protein_coding Homo_sapiens

Loading