C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: itchy E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000374864 ITCH-001 ENSG00000078747 9606 + 20:34363235-34511393 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000374864
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000374864 4.047±0.00 2.077±0.00 2.945±0.00 3.928±2.41 2.022±0.00 0.905±0.20 6.923±0.00 2.431±0.20 0.419±0.00 2.300±1.04 1.916±0.51 3.603±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00098F CIL_00098F_0001 VISTA 20:33968769-34569610
CIL_0003SW CIL_0003SW_0001 CGP 20:34280268-34511393
CIL_0005BA CIL_0005BA_0001 CGP 20:34363235-34540958

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001558 NAS regulation of cell growth
GO:0004842 NAS:IEA ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IBA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0006511 IDA ubiquitin-dependent protein catabolic process
GO:0006915 IEA apoptotic process
GO:0006954 NAS inflammatory response
GO:0007219 TAS Notch signaling pathway
GO:0016020 IDA membrane
GO:0016567 IDA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0032480 TAS negative regulation of type I interferon production
GO:0035519 IDA protein K29-linked ubiquitination
GO:0035872 TAS nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043021 IPI ribonucleoprotein complex binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045236 IPI CXCR chemokine receptor binding
GO:0046329 ISS negative regulation of JNK cascade
GO:0046718 TAS viral entry into host cell
GO:0050687 IMP negative regulation of defense response to virus
GO:0051607 IEA defense response to virus
GO:0070062 IDA extracellular vesicular exosome
GO:0070423 TAS nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 IDA protein K63-linked ubiquitination
GO:0070936 IDA protein K48-linked ubiquitination
GO:0090085 ISS regulation of protein deubiquitination

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029126 Itch-001 protein_coding Mus_musculus 0 3912
ENSMUST00000109685 Itch-002 protein_coding Mus_musculus 0 3725
ENSMUST00000123497 Itch-004 retained_intron Mus_musculus 0 3145
ENSMUST00000142147 Itch-003 processed_transcript Mus_musculus 0 2067
ENSMUST00000138468 Itch-005 retained_intron Mus_musculus 0 817
ENSMUST00000155360 Itch-006 retained_intron Mus_musculus 0 647
ENSMUST00000087332 Gm16223-001 protein_coding Mus_musculus 0 547
ENSMUST00000126648 Itch-007 retained_intron Mus_musculus 0 200

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