C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MDS1 and EVI1 complex locus
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000085276 MECOM 9606 - 3:169083499-169663618 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264674 MECOM-201 169083499-169146305 protein_coding
  ENST00000433243 MECOM-016 169084874-169146288 protein_coding
  ENST00000460814 MECOM-017 169084830-169133970 protein_coding
  ENST00000460890 MECOM-011 169122683-169146288 protein_coding
  ENST00000461430 MECOM-014 169120888-169122672 retained_intron
  ENST00000464456 MECOM-020 169083507-169147734 protein_coding
  ENST00000466623 MECOM-006 169128045-169131880 protein_coding
  ENST00000468789 MECOM-018 169084762-169146675 protein_coding
  ENST00000472280 MECOM-019 169084744-169146305 protein_coding
  ENST00000475754 MECOM-008 169127907-169146539 protein_coding
  ENST00000481315 MECOM-007 169128024-169269238 protein_coding
  ENST00000484519 MECOM-012 169122618-169146568 protein_coding
  ENST00000485957 MECOM-001 169149482-169663618 processed_transcript
  ENST00000486748 MECOM-005 169381259-169663390 protein_coding
  ENST00000487503 MECOM-010 169122683-169146288 protein_coding
  ENST00000492586 MECOM-015 169112788-169128034 protein_coding
  ENST00000494292 MECOM-004 169084761-169663470 protein_coding
  ENST00000494597 MECOM-009 169122683-169146288 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264674ENST00000433243ENST00000460814ENST00000464456ENST00000468789ENST00000484519ENST00000492586ENST00000494292
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264674 N/A N/A N/A N/A 2.543±0.00 N/A N/A N/A 2.067±0.00 N/A 1.566±0.00 0.392±0.00 N/A
ENST00000433243 N/A N/A N/A N/A N/A N/A 0.274±0.00 N/A N/A N/A 1.648±0.00 N/A N/A
ENST00000460814 N/A N/A 0.252±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000464456 0.450±0.00 N/A 0.083±0.00 1.878±1.06 1.693±0.26 0.494±0.00 4.325±0.00 2.301±0.00 0.922±0.00 N/A 1.326±0.00 0.880±0.55 0.392±0.12
ENST00000468789 N/A N/A 0.339±0.00 0.845±0.00 N/A 0.386±0.00 N/A 1.767±0.00 N/A 0.336±0.00 2.030±0.00 0.886±0.00 1.166±0.00
ENST00000484519 N/A 38.439±0.00 N/A 19.451±0.00 13.328±0.00 3.351±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000492586 N/A N/A N/A N/A N/A N/A 0.770±0.00 N/A N/A N/A N/A N/A N/A
ENST00000494292 N/A 4.657±0.00 N/A N/A 1.153±0.00 0.459±0.00 N/A 0.963±0.00 4.223±0.00 N/A 1.901±0.12 0.351±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SS CIL_0008SS_0001 VISTA 3:168815604-169416752
CIL_000921 CIL_000921_0001 VISTA 3:168940545-169545156
CIL_0007J8 CIL_0007J8_0001 UCNEbase 3:168988832-169608246
CIL_0001ZH CIL_0001ZH_0001 CGP 3:169083499-169769895

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000118 IDA histone deacetylase complex
GO:0001701 IEA in utero embryonic development
GO:0001780 IEA neutrophil homeostasis
GO:0003676 IEA nucleic acid binding
GO:0003677 ISS:IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0006954 IEA inflammatory response
GO:0009617 IEA response to bacterium
GO:0009791 IEA post-embryonic development
GO:0016607 IDA nuclear speck
GO:0030154 IEA cell differentiation
GO:0030900 IEA forebrain development
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0042127 IEA regulation of cell proliferation
GO:0042803 IDA protein homodimerization activity
GO:0043069 IMP negative regulation of programmed cell death
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046329 IMP negative regulation of JNK cascade
GO:0046872 IEA metal ion binding
GO:0051726 IDA regulation of cell cycle
GO:0060039 IEA pericardium development
GO:0071425 ISS hematopoietic stem cell proliferation
GO:0072001 IEA renal system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060808 mecom MDS1 and EVI1 complex locus protein_coding Danio_rerio
ENSMUSG00000027684 Mecom MDS1 and EVI1 complex locus protein_coding Mus_musculus

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