C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MDS1 and EVI1 complex locus
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027684 Mecom 10090 - 3:29951299-30548008 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000061088 Mecom-201 30237972-30238319 protein_coding
  ENSMUST00000108270 Mecom-009 29951306-30013505 protein_coding
  ENSMUST00000108271 Mecom-008 29951307-30140423 protein_coding
  ENSMUST00000166001 Mecom-013 29952782-29997702 protein_coding
  ENSMUST00000170212 Mecom-010 29983961-30013061 processed_transcript
  ENSMUST00000172694 Mecom-012 29951299-30013156 protein_coding
  ENSMUST00000172697 Mecom-003 29965456-30509822 protein_coding
  ENSMUST00000172754 Mecom-002 29977344-30548008 nonsense_mediated_decay
  ENSMUST00000173022 Mecom-006 30236569-30509487 processed_transcript
  ENSMUST00000173059 Mecom-007 29952567-30238162 protein_coding
  ENSMUST00000173411 Mecom-004 30014974-30509733 processed_transcript
  ENSMUST00000173495 Mecom-001 29951299-30509733 protein_coding
  ENSMUST00000173899 Mecom-005 29963074-30509514 protein_coding
  ENSMUST00000174406 Mecom-015 29997729-30011439 protein_coding
  ENSMUST00000174413 Mecom-014 29952716-29997663 protein_coding
  ENSMUST00000174428 Mecom-011 29983961-30013204 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000108270ENSMUST00000108271ENSMUST00000166001ENSMUST00000172694ENSMUST00000172697ENSMUST00000172754ENSMUST00000173022ENSMUST00000173059ENSMUST00000173411ENSMUST00000173495ENSMUST00000173899ENSMUST00000174406ENSMUST00000174413ENSMUST00000174428
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000108270 0.602±0.00 0.190±0.07 2.223±0.00 N/A N/A N/A N/A 0.901±0.00 0.145±0.09 0.994±0.00 N/A N/A 0.169±0.00 0.062±0.00
ENSMUST00000108271 N/A N/A 6.094±1.87 N/A N/A 1.675±0.00 N/A 1.713±0.00 N/A N/A 0.403±0.00 N/A N/A N/A
ENSMUST00000166001 N/A 0.184±0.00 N/A 0.168±0.00 0.477±0.16 N/A N/A N/A 0.168±0.02 N/A 0.290±0.00 1.535±0.28 0.380±0.23 0.056±0.00
ENSMUST00000172694 N/A N/A N/A 0.265±0.00 N/A N/A N/A N/A 0.147±0.05 N/A 0.426±0.08 0.738±0.24 0.122±0.03 N/A
ENSMUST00000172697 N/A 0.415±0.00 N/A N/A 0.603±0.18 N/A N/A 1.381±0.00 0.073±0.04 N/A 0.304±0.00 1.200±0.43 N/A N/A
ENSMUST00000172754 N/A N/A N/A N/A 0.286±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000173022 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.041±0.00
ENSMUST00000173059 3.178±1.86 0.259±0.09 N/A N/A 0.514±0.19 4.918±1.10 0.587±0.01 2.490±0.21 0.132±0.00 2.666±0.57 N/A 2.291±0.40 N/A 0.038±0.00
ENSMUST00000173411 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.072±0.00
ENSMUST00000173495 1.445±0.82 0.236±0.04 4.325±1.63 0.498±0.30 0.401±0.03 3.294±0.28 0.345±0.01 1.797±0.48 0.087±0.03 2.642±1.23 N/A 1.375±1.18 0.177±0.01 0.052±0.00
ENSMUST00000173899 0.988±0.01 N/A N/A N/A 0.732±0.39 2.432±0.16 0.876±0.15 1.953±0.03 N/A 2.749±0.80 N/A 1.426±0.34 N/A N/A
ENSMUST00000174406 N/A N/A N/A N/A N/A N/A N/A N/A 0.323±0.00 N/A N/A N/A N/A N/A
ENSMUST00000174413 N/A 0.212±0.00 N/A N/A N/A N/A N/A N/A 0.166±0.00 N/A N/A N/A N/A 0.180±0.00
ENSMUST00000174428 N/A N/A N/A N/A N/A N/A N/A N/A 0.044±0.00 N/A N/A 0.947±0.00 N/A 0.056±0.02

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000711 CIL_000711_0002 CGP 3:29082023-30548008
CIL_0008SS CIL_0008SS_0002 VISTA 3:29679822-30280970
CIL_000921 CIL_000921_0002 VISTA 3:29804532-30409280
CIL_0007J8 CIL_0007J8_0002 UCNEbase 3:29834894-30452898
CIL_0001ZH CIL_0001ZH_0002 CGP 3:29951299-30599939

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000118 ISS histone deacetylase complex
GO:0001701 IMP in utero embryonic development
GO:0001780 IMP neutrophil homeostasis
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006915 IEA apoptotic process
GO:0006954 IMP inflammatory response
GO:0009617 IMP response to bacterium
GO:0009791 IMP post-embryonic development
GO:0016607 ISS nuclear speck
GO:0030154 IEA cell differentiation
GO:0030900 IMP forebrain development
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035116 IMP embryonic hindlimb morphogenesis
GO:0042127 IMP regulation of cell proliferation
GO:0042803 ISS protein homodimerization activity
GO:0043069 ISS negative regulation of programmed cell death
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046329 ISS negative regulation of JNK cascade
GO:0046872 IEA metal ion binding
GO:0051726 ISS regulation of cell cycle
GO:0060039 IMP pericardium development
GO:0071425 IMP hematopoietic stem cell proliferation
GO:0072001 IGI renal system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060808 mecom MDS1 and EVI1 complex locus protein_coding Danio_rerio
ENSG00000085276 MECOM MDS1 and EVI1 complex locus protein_coding Homo_sapiens

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