C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000087245 MMP2 9606 + 16:55389700-55506691 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000219070 MMP2-001 55478971-55506691 protein_coding
  ENST00000437642 MMP2-003 55481557-55505759 protein_coding
  ENST00000543485 MMP2-002 55480533-55505525 protein_coding
  ENST00000564864 MMP2-004 55479998-55485776 protein_coding
  ENST00000566564 MMP2-005 55505375-55506239 nonsense_mediated_decay
  ENST00000568715 MMP2-007 55478830-55485352 protein_coding
  ENST00000570283 MMP2-006 55488662-55502889 protein_coding
  ENST00000570308 MMP2-008 55389700-55506237 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000219070ENST00000437642ENST00000543485ENST00000564864ENST00000566564ENST00000570283ENST00000570308
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000219070 160.351±0.00 4.443±0.00 1.036±0.00 0.197±0.09 20.144±7.78 17.419±12.95 5.071±2.95 1.955±1.59 6.240±5.31 15.342±10.23 3.816±2.06 27.732±21.21 36.056±15.06 13.388±8.95
ENST00000437642 N/A N/A 0.848±0.00 0.150±0.00 N/A N/A 1.994±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000543485 194.921±0.00 9.945±0.00 0.930±0.00 0.927±0.00 27.068±6.17 7.315±0.00 2.005±0.00 4.355±3.42 9.909±0.00 5.236±0.00 1.374±0.00 23.294±11.82 89.904±0.00 N/A
ENST00000564864 N/A N/A 3.199±0.00 N/A 25.877±0.00 N/A N/A 1.581±0.00 20.523±0.00 12.810±0.00 N/A 12.732±0.00 N/A N/A
ENST00000566564 N/A N/A N/A 1.338±0.00 N/A N/A N/A N/A 4.069±0.00 N/A N/A N/A N/A N/A
ENST00000570283 N/A N/A N/A N/A N/A N/A N/A N/A 18.349±0.00 N/A N/A 38.998±0.00 114.880±0.00 23.417±0.00
ENST00000570308 N/A N/A N/A N/A 11.842±0.00 N/A N/A N/A N/A N/A 2.076±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ON CIL_0007ON_0002 UCNEbase 16:51906374-55391377
CIL_00098A CIL_00098A_0001 VISTA 16:54889273-55490371
CIL_000987 CIL_000987_0001 VISTA 16:54906681-55507962
CIL_0007WY CIL_0007WY_0001 VISTA 16:54995377-55596848
CIL_000988 CIL_000988_0001 VISTA 16:55084120-55684969
CIL_00098D CIL_00098D_0001 VISTA 16:55090504-55691826
CIL_0001GQ CIL_0001GQ_0001 CGP 16:55323760-55506691
CIL_0005P6 CIL_0005P6_0001 CGP 16:55389700-55586670

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001666 IEA response to hypoxia
GO:0001955 IEA blood vessel maturation
GO:0001957 IEA intramembranous ossification
GO:0004222 IEA metalloendopeptidase activity
GO:0004252 TAS serine-type endopeptidase activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005886 IEA plasma membrane
GO:0006508 IEA proteolysis
GO:0007566 IEA embryo implantation
GO:0008237 IEA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0022617 TAS extracellular matrix disassembly
GO:0030017 IEA sarcomere
GO:0030198 TAS extracellular matrix organization
GO:0030574 TAS collagen catabolic process
GO:0031012 IEA extracellular matrix
GO:0035987 IEP endodermal cell differentiation
GO:0044267 TAS cellular protein metabolic process
GO:0045089 IEA positive regulation of innate immune response
GO:0048705 IEA skeletal system morphogenesis
GO:0060325 IEA face morphogenesis
GO:0060346 IEA bone trabecula formation
GO:0071230 IEA cellular response to amino acid stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017676 mmp2 matrix metalloproteinase 2 protein_coding Danio_rerio
ENSMUSG00000031740 Mmp2 matrix metallopeptidase 2 protein_coding Mus_musculus

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