C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DNA (cytosine-5-)-methyltransferase 3 beta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000088305 DNMT3B 9606 + 20:32762385-32809356 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000201963 DNMT3B-004 32779852-32809356 protein_coding
  ENST00000328111 DNMT3B-001 32762385-32809356 protein_coding
  ENST00000348286 DNMT3B-003 32762424-32809356 protein_coding
  ENST00000353855 DNMT3B-002 32762424-32809356 protein_coding
  ENST00000443239 DNMT3B-006 32762596-32808280 protein_coding
  ENST00000456297 DNMT3B-005 32762642-32808069 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000201963ENST00000328111ENST00000348286ENST00000353855ENST00000443239ENST00000456297
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000201963 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.331±0.00
ENST00000328111 N/A N/A N/A N/A N/A N/A 0.047±0.00 N/A N/A N/A 1.457±0.00 0.608±0.00 N/A
ENST00000348286 0.116±0.00 0.045±0.00 N/A 0.054±0.00 0.330±0.00 0.147±0.00 N/A N/A 0.151±0.04 N/A 0.548±0.10 0.860±0.00 0.418±0.00
ENST00000353855 N/A 0.221±0.00 0.064±0.00 N/A 0.066±0.00 N/A N/A 0.029±0.00 N/A N/A 4.181±3.87 0.607±0.27 1.771±0.75
ENST00000443239 N/A N/A N/A 0.168±0.00 N/A N/A N/A N/A N/A N/A 0.279±0.00 N/A N/A
ENST00000456297 N/A N/A N/A N/A N/A N/A 0.203±0.00 0.137±0.00 N/A 0.034±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008A4 CIL_0008A4_0001 VISTA 20:32224531-32829311
CIL_0008NQ CIL_0008NQ_0001 VISTA 20:32326689-32928341
CIL_0008QN CIL_0008QN_0001 VISTA 20:32676112-33281064
CIL_00036W CIL_00036W_0001 CGP 20:32702691-32809356
CIL_0001KC CIL_0001KC_0001 CGP 20:32762385-32850405

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000792 IEA heterochromatin
GO:0003677 IEA DNA binding
GO:0003714 IDA transcription corepressor activity
GO:0003886 TAS DNA (cytosine-5-)-methyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005720 IEA nuclear heterochromatin
GO:0005737 IEA cytoplasm
GO:0006306 TAS DNA methylation
GO:0006346 IEA methylation-dependent chromatin silencing
GO:0006349 IEA regulation of gene expression by genetic imprinting
GO:0008168 IEA methyltransferase activity
GO:0009008 NAS DNA-methyltransferase activity
GO:0010212 IEA response to ionizing radiation
GO:0010424 IEA DNA methylation on cytosine within a CG sequence
GO:0010628 IMP positive regulation of gene expression
GO:0031503 IEA protein complex localization
GO:0042493 IEA response to drug
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045322 IEA unmethylated CpG binding
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0046498 IEA S-adenosylhomocysteine metabolic process
GO:0046499 IEA S-adenosylmethioninamine metabolic process
GO:0046872 IEA metal ion binding
GO:0051571 IMP positive regulation of histone H3-K4 methylation
GO:0051573 IMP negative regulation of histone H3-K9 methylation
GO:0051718 IEA DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0071230 IEA cellular response to amino acid stimulus
GO:0090116 IEA C-5 methylation of cytosine

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036791 dnmt4 DNA (cytosine-5-)-methyltransferase 4 protein_coding Danio_rerio
ENSMUSG00000027478 Dnmt3b DNA methyltransferase 3B protein_coding Mus_musculus

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