C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DNA methyltransferase 3B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027478 Dnmt3b 10090 + 2:153649450-153687730 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000056495 Dnmt3b-201 153649454-153687726 protein_coding
  ENSMUST00000072997 Dnmt3b-002 153649450-153687730 protein_coding
  ENSMUST00000081628 Dnmt3b-004 153649453-153687730 protein_coding
  ENSMUST00000088976 Dnmt3b-005 153649454-153687730 protein_coding
  ENSMUST00000103150 Dnmt3b-008 153649454-153687730 protein_coding
  ENSMUST00000103151 Dnmt3b-006 153649453-153687730 protein_coding
  ENSMUST00000109771 Dnmt3b-009 153649617-153687316 protein_coding
  ENSMUST00000109772 Dnmt3b-007 153649454-153687730 protein_coding
  ENSMUST00000109773 Dnmt3b-003 153649450-153687730 protein_coding
  ENSMUST00000109774 Dnmt3b-001 153649453-153687730 protein_coding
  ENSMUST00000132132 Dnmt3b-010 153665802-153667959 retained_intron
  ENSMUST00000140811 Dnmt3b-011 153669370-153670416 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000056495ENSMUST00000072997ENSMUST00000081628ENSMUST00000088976ENSMUST00000103150ENSMUST00000103151ENSMUST00000109771ENSMUST00000109772ENSMUST00000109773
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000056495 N/A N/A N/A N/A N/A N/A N/A 0.117±0.03 0.266±0.08 N/A N/A 0.446±0.10 0.595±0.16 N/A
ENSMUST00000072997 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.013±0.00 N/A N/A N/A
ENSMUST00000081628 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.395±0.00 N/A 0.440±0.00 N/A N/A
ENSMUST00000088976 N/A N/A N/A N/A N/A N/A N/A 0.163±0.03 0.457±0.00 N/A N/A N/A 1.422±0.00 N/A
ENSMUST00000103150 0.285±0.14 0.332±0.14 0.174±0.03 0.246±0.00 0.360±0.11 0.335±0.17 N/A 0.233±0.00 0.525±0.19 0.541±0.23 N/A 1.097±0.45 2.198±1.12 0.226±0.00
ENSMUST00000103151 0.447±0.22 0.149±0.05 0.315±0.05 0.643±0.10 0.713±0.00 0.467±0.18 0.082±0.00 N/A 1.416±0.52 0.283±0.09 0.123±0.10 0.802±0.43 1.223±0.24 0.428±0.09
ENSMUST00000109771 0.834±0.19 N/A 0.203±0.03 0.336±0.00 0.296±0.00 0.341±0.07 0.106±0.03 0.128±0.00 0.620±0.36 0.324±0.04 0.055±0.01 0.804±0.13 2.381±1.98 0.198±0.03
ENSMUST00000109772 N/A N/A N/A N/A N/A N/A N/A 0.252±0.00 0.230±0.00 N/A 0.088±0.01 0.452±0.14 1.379±0.60 N/A
ENSMUST00000109773 0.122±0.00 N/A 0.112±0.00 N/A N/A N/A N/A 0.129±0.00 N/A 0.115±0.00 0.151±0.04 0.786±0.00 N/A 0.547±0.08

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008A4 CIL_0008A4_0002 VISTA 2:153181176-153785061
CIL_0008NQ CIL_0008NQ_0002 VISTA 2:153260290-153861940
CIL_0008QN CIL_0008QN_0002 VISTA 2:153551282-154154369
CIL_00036W CIL_00036W_0002 CGP 2:153616933-153687730
CIL_0001KC CIL_0001KC_0002 CGP 2:153649450-153773310

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000775 IDA chromosome, centromeric region
GO:0000792 IDA heterochromatin
GO:0003677 IDA DNA binding
GO:0003714 IEA transcription corepressor activity
GO:0003886 IDA DNA (cytosine-5-)-methyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005720 IDA nuclear heterochromatin
GO:0005737 IEA cytoplasm
GO:0006306 IGI DNA methylation
GO:0006346 IGI methylation-dependent chromatin silencing
GO:0006349 IMP regulation of gene expression by genetic imprinting
GO:0008168 IDA methyltransferase activity
GO:0010212 IEA response to ionizing radiation
GO:0010424 IEA DNA methylation on cytosine within a CG sequence
GO:0010628 IEA positive regulation of gene expression
GO:0031503 IDA protein complex localization
GO:0042493 IEA response to drug
GO:0043045 IEP DNA methylation involved in embryo development
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045322 IEA unmethylated CpG binding
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045814 IMP negative regulation of gene expression, epigenetic
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0046498 IEA S-adenosylhomocysteine metabolic process
GO:0046499 IEA S-adenosylmethioninamine metabolic process
GO:0046872 IEA metal ion binding
GO:0051571 IEA positive regulation of histone H3-K4 methylation
GO:0051573 IEA negative regulation of histone H3-K9 methylation
GO:0051718 IEA DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0071230 IDA cellular response to amino acid stimulus
GO:0090116 IDA C-5 methylation of cytosine

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036791 dnmt4 DNA (cytosine-5-)-methyltransferase 4 protein_coding Danio_rerio
ENSG00000088305 DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta protein_coding Homo_sapiens

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