C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SH2 domain containing 3C
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000095370 SH2D3C 9606 - 9:127738317-127778741 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314830 SH2D3C-004 127738319-127778741 protein_coding
  ENST00000373276 SH2D3C-201 127738318-127771369 protein_coding
  ENST00000373277 SH2D3C-007 127738317-127771438 protein_coding
  ENST00000414380 SH2D3C-010 127749212-127755030 protein_coding
  ENST00000420366 SH2D3C-008 127738318-127755304 protein_coding
  ENST00000429553 SH2D3C-202 127738318-127762418 protein_coding
  ENST00000440630 SH2D3C-002 127744898-127762416 protein_coding
  ENST00000464239 SH2D3C-005 127745018-127762188 processed_transcript
  ENST00000468969 SH2D3C-009 127741845-127778710 processed_transcript
  ENST00000471939 SH2D3C-001 127742849-127774144 processed_transcript
  ENST00000484160 SH2D3C-011 127742659-127744720 processed_transcript
  ENST00000488685 SH2D3C-003 127747147-127762287 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000314830ENST00000373276ENST00000373277ENST00000414380ENST00000420366ENST00000429553ENST00000440630ENST00000471939ENST00000484160ENST00000488685
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000314830 4.067±0.00 5.566±0.00 0.062±0.00 N/A N/A N/A N/A N/A 0.189±0.00 N/A N/A 1.288±0.28 2.203±1.19 N/A
ENST00000373276 N/A N/A 0.039±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000373277 9.930±0.00 22.574±0.00 0.186±0.00 1.507±0.00 4.622±0.00 2.164±0.00 1.019±0.61 4.840±0.00 0.503±0.33 8.219±0.00 0.723±0.00 3.282±3.16 4.932±3.14 5.002±0.00
ENST00000414380 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.616±0.00 N/A N/A N/A
ENST00000420366 N/A N/A N/A 2.172±1.87 1.890±0.00 N/A 1.538±0.00 0.394±0.00 N/A N/A 0.861±0.00 N/A N/A 0.577±0.00
ENST00000429553 N/A N/A N/A N/A 1.030±0.62 N/A N/A N/A N/A 8.955±0.00 N/A 1.454±1.05 N/A N/A
ENST00000440630 N/A N/A 0.415±0.00 0.362±0.00 1.945±0.00 N/A 0.821±0.00 N/A 1.299±0.00 N/A N/A 0.590±0.00 N/A N/A
ENST00000471939 N/A N/A N/A 0.307±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000484160 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.468±0.00 N/A N/A
ENST00000488685 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.430±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YA CIL_0008YA_0001 VISTA 9:127227593-127829012
CIL_0002CG CIL_0002CG_0002 CGP 9:127731524-127778741

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0007254 TAS JNK cascade
GO:0007264 IEA small GTPase mediated signal transduction
GO:0009967 TAS positive regulation of signal transduction
GO:0016020 IEA membrane
GO:0043547 IEA positive regulation of GTPase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009081 sh2d3cb SH2 domain containing 3Cb protein_coding Danio_rerio
ENSDARG00000028099 sh2d3ca SH2 domain containing 3Ca protein_coding Danio_rerio
ENSMUSG00000059013 Sh2d3c SH2 domain containing 3C protein_coding Mus_musculus

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