C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: platelet-derived growth factor beta polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000100311 PDGFB 9606 - 22:39223359-39244751 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000331163 PDGFB-001 39223359-39244751 protein_coding
  ENST00000381551 PDGFB-002 39224935-39240909 protein_coding
  ENST00000440375 PDGFB-004 39230184-39241130 protein_coding
  ENST00000455790 PDGFB-003 39230159-39243016 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000331163ENST00000381551ENST00000440375ENST00000455790
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000331163 2.976±0.00 4.214±0.00 0.156±0.00 2.583±0.00 1.258±0.73 2.497±2.36 2.256±1.15 1.790±1.66 0.514±0.26 8.946±8.00 1.065±0.36 1.914±0.61 16.918±3.52 0.835±0.59
ENST00000381551 N/A 4.181±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.683±0.00 N/A N/A N/A
ENST00000440375 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.951±0.00
ENST00000455790 N/A N/A N/A N/A N/A 0.629±0.00 2.169±0.00 1.124±0.00 N/A N/A N/A 3.242±0.00 23.144±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005NO CIL_0005NO_0001 CGP 22:39120167-39244751
CIL_0003NT CIL_0003NT_0001 CGP 22:39223359-39320389

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 TAS Golgi membrane
GO:0001568 IEA blood vessel development
GO:0001666 IEA response to hypoxia
GO:0001892 ISS embryonic placenta development
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0002548 IDA monocyte chemotaxis
GO:0002576 TAS platelet degranulation
GO:0003104 ISS positive regulation of glomerular filtration
GO:0005102 IEA receptor binding
GO:0005161 NAS platelet-derived growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005518 IDA collagen binding
GO:0005576 NAS extracellular region
GO:0005615 IBA extracellular space
GO:0005737 ISS cytoplasm
GO:0005788 TAS endoplasmic reticulum lumen
GO:0006260 IEA DNA replication
GO:0006468 IDA protein phosphorylation
GO:0006929 IEA substrate-dependent cell migration
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007179 ISS transforming growth factor beta receptor signaling pathway
GO:0007507 ISS heart development
GO:0007596 TAS blood coagulation
GO:0008083 IEA:IDA growth factor activity
GO:0008284 IDA positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009611 NAS response to wounding
GO:0009986 IDA cell surface
GO:0010033 IEA response to organic substance
GO:0010512 IDA negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 IDA negative regulation of platelet activation
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 IEA response to organic cyclic compound
GO:0014911 IDA positive regulation of smooth muscle cell migration
GO:0016020 IEA membrane
GO:0016049 IEA cell growth
GO:0016176 IDA superoxide-generating NADPH oxidase activator activity
GO:0016323 ISS basolateral plasma membrane
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030031 IEA cell projection assembly
GO:0030036 IEA actin cytoskeleton organization
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030335 IDA positive regulation of cell migration
GO:0030336 IEA negative regulation of cell migration
GO:0031093 TAS platelet alpha granule lumen
GO:0031954 IDA positive regulation of protein autophosphorylation
GO:0032147 IDA activation of protein kinase activity
GO:0032148 IDA activation of protein kinase B activity
GO:0032355 IEA response to estradiol
GO:0032868 IEA response to insulin
GO:0035793 IDA positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 ISS paracrine signaling
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042056 IDA chemoattractant activity
GO:0042060 IEA wound healing
GO:0042127 IEA regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0042802 IPI identical protein binding
GO:0042803 IDA protein homodimerization activity
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0043410 IMP positive regulation of MAPK cascade
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0043552 IDA positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 IEA response to estrogen
GO:0045087 TAS innate immune response
GO:0045737 IDA positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740 IDA positive regulation of DNA replication
GO:0045743 IEA positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840 IDA positive regulation of mitosis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045977 IEA positive regulation of mitotic cell cycle, embryonic
GO:0046982 IPI protein heterodimerization activity
GO:0048008 IDA platelet-derived growth factor receptor signaling pathway
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048146 IDA positive regulation of fibroblast proliferation
GO:0048407 IPI platelet-derived growth factor binding
GO:0048514 IEA blood vessel morphogenesis
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0050730 IEA regulation of peptidyl-tyrosine phosphorylation
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 IDA positive chemotaxis
GO:0050921 IDA positive regulation of chemotaxis
GO:0051781 IEA positive regulation of cell division
GO:0060326 IDA cell chemotaxis
GO:0060445 IEA branching involved in salivary gland morphogenesis
GO:0060664 IEA epithelial cell proliferation involved in salivary gland morphogenesis
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071506 ISS cellular response to mycophenolic acid
GO:0072126 IDA positive regulation of glomerular mesangial cell proliferation
GO:0072255 ISS metanephric glomerular mesangial cell development
GO:0072262 IEA metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264 IEA metanephric glomerular endothelium development
GO:0072593 IMP reactive oxygen species metabolic process
GO:0090280 IDA positive regulation of calcium ion import
GO:1900127 IDA positive regulation of hyaluronan biosynthetic process
GO:2000379 IDA positive regulation of reactive oxygen species metabolic process
GO:2000573 IDA positive regulation of DNA biosynthetic process
GO:2000591 IDA positive regulation of metanephric mesenchymal cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038139 PDGFB (1 of 3) platelet-derived growth factor beta polypeptide protein_coding Danio_rerio
ENSDARG00000040839 PDGFB (2 of 3) platelet-derived growth factor beta polypeptide protein_coding Danio_rerio
ENSDARG00000086778 pdgfb platelet derived growth factor, B polypeptide protein_coding Danio_rerio
ENSMUSG00000000489 Pdgfb platelet derived growth factor, B polypeptide protein_coding Mus_musculus

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