C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: platelet derived growth factor, B polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000489 Pdgfb 10090 - 15:79995900-80014808 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000500 Pdgfb-201 79995900-80014808 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000500
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000500 21.170±7.59 25.894±2.50 3.615±0.31 4.622±0.65 10.318±5.59 5.778±1.01 10.223±5.54 8.150±3.00 0.691±0.33 36.994±11.30 6.411±1.90 10.631±4.58 13.533±13.98 0.577±0.32

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005NO CIL_0005NO_0002 CGP 15:79915807-80014808
CIL_0003NT CIL_0003NT_0002 CGP 15:79995900-80091868

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001568 IEP blood vessel development
GO:0001666 IEA response to hypoxia
GO:0001892 IMP embryonic placenta development
GO:0001938 IGI positive regulation of endothelial cell proliferation
GO:0002548 ISS monocyte chemotaxis
GO:0003104 IMP positive regulation of glomerular filtration
GO:0005102 IEA receptor binding
GO:0005161 ISS platelet-derived growth factor receptor binding
GO:0005515 IEA protein binding
GO:0005518 IEA collagen binding
GO:0005615 IBA extracellular space
GO:0005737 ISS cytoplasm
GO:0006260 IEA DNA replication
GO:0006468 ISS protein phosphorylation
GO:0006929 IDA substrate-dependent cell migration
GO:0007179 ISS transforming growth factor beta receptor signaling pathway
GO:0007507 IMP heart development
GO:0007596 IBA blood coagulation
GO:0008083 ISS growth factor activity
GO:0008284 ISS positive regulation of cell proliferation
GO:0009611 ISS response to wounding
GO:0009986 ISS cell surface
GO:0010033 IEA response to organic substance
GO:0010512 ISS negative regulation of phosphatidylinositol biosynthetic process
GO:0010544 ISS negative regulation of platelet activation
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014070 IEA response to organic cyclic compound
GO:0014911 IMP positive regulation of smooth muscle cell migration
GO:0016049 IEA cell growth
GO:0016176 ISS superoxide-generating NADPH oxidase activator activity
GO:0016323 ISS basolateral plasma membrane
GO:0018105 ISS peptidyl-serine phosphorylation
GO:0018108 ISS peptidyl-tyrosine phosphorylation
GO:0030031 IDA cell projection assembly
GO:0030036 IDA actin cytoskeleton organization
GO:0030335 IGI positive regulation of cell migration
GO:0030336 IGI negative regulation of cell migration
GO:0031954 ISS positive regulation of protein autophosphorylation
GO:0032147 ISS activation of protein kinase activity
GO:0032148 ISS activation of protein kinase B activity
GO:0032355 IEA response to estradiol
GO:0032868 IEA response to insulin
GO:0035793 ISS positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0038001 IMP paracrine signaling
GO:0038033 TAS positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042056 IEA chemoattractant activity
GO:0042060 IEA wound healing
GO:0042127 IEA regulation of cell proliferation
GO:0042493 IEA response to drug
GO:0042802 IEA identical protein binding
GO:0042803 ISS protein homodimerization activity
GO:0043406 ISS positive regulation of MAP kinase activity
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043536 ISS positive regulation of blood vessel endothelial cell migration
GO:0043552 ISS positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 IEA response to estrogen
GO:0045737 ISS positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045740 ISS positive regulation of DNA replication
GO:0045743 IDA positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045840 ISS positive regulation of mitosis
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045907 TAS positive regulation of vasoconstriction
GO:0045908 TAS negative regulation of vasodilation
GO:0045977 IGI positive regulation of mitotic cell cycle, embryonic
GO:0046982 IEA protein heterodimerization activity
GO:0048008 ISS platelet-derived growth factor receptor signaling pathway
GO:0048146 ISS positive regulation of fibroblast proliferation
GO:0048407 IEA platelet-derived growth factor binding
GO:0048514 IDA blood vessel morphogenesis
GO:0048661 IMP positive regulation of smooth muscle cell proliferation
GO:0050730 IDA regulation of peptidyl-tyrosine phosphorylation
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 IEA positive chemotaxis
GO:0050921 ISS positive regulation of chemotaxis
GO:0051781 IEA positive regulation of cell division
GO:0060326 ISS cell chemotaxis
GO:0060445 IMP branching involved in salivary gland morphogenesis
GO:0060664 IMP epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060947 TAS cardiac vascular smooth muscle cell differentiation
GO:0061098 ISS positive regulation of protein tyrosine kinase activity
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071506 ISS cellular response to mycophenolic acid
GO:0072126 ISS positive regulation of glomerular mesangial cell proliferation
GO:0072255 IMP metanephric glomerular mesangial cell development
GO:0072262 IMP metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072264 IEP metanephric glomerular endothelium development
GO:0072593 ISS reactive oxygen species metabolic process
GO:0090280 ISS positive regulation of calcium ion import
GO:1900127 ISS positive regulation of hyaluronan biosynthetic process
GO:2000379 ISS positive regulation of reactive oxygen species metabolic process
GO:2000573 ISS positive regulation of DNA biosynthetic process
GO:2000591 IEA positive regulation of metanephric mesenchymal cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038139 PDGFB (1 of 3) platelet-derived growth factor beta polypeptide protein_coding Danio_rerio
ENSDARG00000040839 PDGFB (2 of 3) platelet-derived growth factor beta polypeptide protein_coding Danio_rerio
ENSDARG00000086778 pdgfb platelet derived growth factor, B polypeptide protein_coding Danio_rerio
ENSG00000100311 PDGFB platelet-derived growth factor beta polypeptide protein_coding Homo_sapiens

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