C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: APEX nuclease (multifunctional DNA repair enzyme) 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000216714 APEX1-001 ENSG00000100823 9606 + 14:20455195-20457767 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000216714
Transcript ID Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000216714 4.755±0.00 12.344±0.00 8.824±0.00 7.864±0.00 2.497±0.00 5.656±0.00 10.019±0.00 3.961±0.00 2.503±0.00 30.476±16.13 34.541±10.18 7.153±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004Z3 CIL_0004Z3_0002 CGP 14:20446411-20457772
CIL_0001O8 CIL_0001O8_0001 CGP 14:20455191-20461612

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000737 IEA DNA catabolic process, endonucleolytic
GO:0000738 IBA DNA catabolic process, exonucleolytic
GO:0003677 IEA:IDA DNA binding
GO:0003684 IDA damaged DNA binding
GO:0003713 IDA transcription coactivator activity
GO:0003714 TAS transcription corepressor activity
GO:0003906 IDA DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518 IEA nuclease activity
GO:0004519 IDA endonuclease activity
GO:0004520 TAS endodeoxyribonuclease activity
GO:0004521 IEA endoribonuclease activity
GO:0004523 TAS RNA-DNA hybrid ribonuclease activity
GO:0004528 TAS phosphodiesterase I activity
GO:0004844 TAS uracil DNA N-glycosylase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 TAS endoplasmic reticulum
GO:0005813 IDA centrosome
GO:0005840 TAS ribosome
GO:0006281 IEA:IDA DNA repair
GO:0006284 IBA base-excision repair
GO:0006310 IEA DNA recombination
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007568 IEA aging
GO:0008081 IDA phosphoric diester hydrolase activity
GO:0008311 IBA double-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 TAS 3'-5' exonuclease activity
GO:0010243 IEA response to organonitrogen compound
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0016491 IDA oxidoreductase activity
GO:0016607 IDA nuclear speck
GO:0016890 IDA site-specific endodeoxyribonuclease activity, specific for altered base
GO:0031490 IDA chromatin DNA binding
GO:0032403 IEA protein complex binding
GO:0042493 IEA response to drug
GO:0043488 IMP regulation of mRNA stability
GO:0044822 IDA poly(A) RNA binding
GO:0045454 IEA cell redox homeostasis
GO:0045739 IDA positive regulation of DNA repair
GO:0046872 IDA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051059 IEA NF-kappaB binding
GO:0055114 IDA oxidation-reduction process
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071320 IEA cellular response to cAMP
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071417 IEA cellular response to organonitrogen compound
GO:0080111 IDA DNA demethylation
GO:0090305 TAS nucleic acid phosphodiester bond hydrolysis
GO:0090502 TAS RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900087 IEA positive regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000049411 Apex1-001 protein_coding Mus_musculus 0 1072
ENSMUST00000136753 Apex1-004 protein_coding Mus_musculus 0 595
ENSMUST00000160835 Tmem55b-001 protein_coding Mus_musculus 0 595
ENSMUST00000128395 Apex1-003 protein_coding Mus_musculus 0 501

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