C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101665 SMAD7 9606 - 18:48919853-48950711 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000262158 SMAD7-001 48919853-48950711 protein_coding
  ENST00000545051 SMAD7-003 48920027-48942807 retained_intron
  ENST00000585986 SMAD7-006 48921501-48942732 processed_transcript
  ENST00000586093 SMAD7-007 48921534-48948505 protein_coding
  ENST00000587336 SMAD7-004 48921411-48930182 processed_transcript
  ENST00000588190 SMAD7-008 48921641-48933722 processed_transcript
  ENST00000589634 SMAD7-005 48921372-48950424 protein_coding
  ENST00000591805 SMAD7-002 48920993-48949333 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000262158ENST00000545051ENST00000585986ENST00000586093ENST00000588190ENST00000589634ENST00000591805
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000262158 N/A 2.193±0.00 0.616±0.00 0.554±0.01 N/A 2.570±0.00 0.207±0.00 1.519±0.65 0.637±0.00 2.564±0.38 2.088±0.00 3.260±0.91 3.353±1.11 N/A
ENST00000545051 5.046±0.00 4.356±0.00 N/A 0.580±0.00 2.344±0.00 N/A N/A 2.169±0.00 0.541±0.00 N/A N/A 4.164±2.52 6.034±4.29 1.379±0.36
ENST00000585986 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.997±0.00 N/A N/A
ENST00000586093 N/A N/A N/A N/A N/A N/A N/A N/A 2.246±0.00 N/A N/A N/A N/A N/A
ENST00000588190 N/A N/A N/A N/A 2.878±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000589634 N/A N/A 1.001±0.00 0.871±0.00 2.229±0.00 1.209±0.00 N/A N/A 2.572±0.00 N/A N/A N/A N/A N/A
ENST00000591805 6.823±0.00 N/A 1.843±0.00 1.348±0.57 4.870±0.00 2.614±1.52 0.530±0.00 N/A 1.298±0.45 1.773±0.00 N/A N/A N/A 0.417±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P6 CIL_0008P6_0001 VISTA 18:48477632-49083007
CIL_0007UR CIL_0007UR_0001 VISTA 18:48480781-49082143
CIL_0000B3 CIL_0000B3_0002 CGP 18:48539046-48950711
CIL_0000B2 CIL_0000B2_0002 CGP 18:48919853-49461347

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001657 IEA ureteric bud development
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005518 IEA collagen binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005913 IDA cell-cell adherens junction
GO:0006351 TAS transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007179 TAS:IEA transforming growth factor beta receptor signaling pathway
GO:0008013 IPI beta-catenin binding
GO:0010467 TAS gene expression
GO:0010719 IC negative regulation of epithelial to mesenchymal transition
GO:0010801 IDA negative regulation of peptidyl-threonine phosphorylation
GO:0010944 IDA negative regulation of transcription by competitive promoter binding
GO:0016342 IDA catenin complex
GO:0017015 IC regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 IDA positive regulation of cell-cell adhesion
GO:0030336 TAS negative regulation of cell migration
GO:0030509 TAS BMP signaling pathway
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 IDA negative regulation of BMP signaling pathway
GO:0030617 IDA transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
GO:0031397 IDA negative regulation of protein ubiquitination
GO:0031398 IDA positive regulation of protein ubiquitination
GO:0031625 IPI ubiquitin protein ligase binding
GO:0032436 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 IDA regulation of activin receptor signaling pathway
GO:0033137 IDA negative regulation of peptidyl-serine phosphorylation
GO:0034333 IMP adherens junction assembly
GO:0034616 IEP response to laminar fluid shear stress
GO:0034629 IDA cellular protein complex localization
GO:0034713 IPI type I transforming growth factor beta receptor binding
GO:0035556 IEA intracellular signal transduction
GO:0043234 IDA protein complex
GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045944 TAS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048185 IPI activin binding
GO:0048844 ISS artery morphogenesis
GO:0050821 IDA protein stabilization
GO:0051444 IDA negative regulation of ubiquitin-protein transferase activity
GO:0055010 ISS ventricular cardiac muscle tissue morphogenesis
GO:0055117 ISS regulation of cardiac muscle contraction
GO:0060373 IC regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 ISS pathway-restricted SMAD protein phosphorylation
GO:0060394 IDA negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412 ISS ventricular septum morphogenesis
GO:0070411 IPI I-SMAD binding
GO:0071560 IMP cellular response to transforming growth factor beta stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016858 smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000025880 Smad7 SMAD family member 7 protein_coding Mus_musculus

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