C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MCF.2 cell line derived transforming sequence
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000101977 MCF2 9606 - X:139581770-139708227 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000338585 MCF2-004 139582471-139642518 protein_coding
  ENST00000370573 MCF2-003 139582443-139642518 protein_coding
  ENST00000370576 MCF2-002 139581771-139642728 protein_coding
  ENST00000414978 MCF2-201 139581771-139708216 protein_coding
  ENST00000437564 MCF2-006 139581771-139605779 protein_coding
  ENST00000446225 MCF2-005 139582142-139615052 protein_coding
  ENST00000483690 MCF2-007 139607184-139614950 processed_transcript
  ENST00000519895 MCF2-008 139582297-139708227 protein_coding
  ENST00000520602 MCF2-001 139581770-139692156 protein_coding
  ENST00000536274 MCF2-202 139581771-139642841 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000338585ENST00000370573ENST00000370576ENST00000414978ENST00000437564ENST00000446225ENST00000483690ENST00000519895ENST00000520602
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000338585 N/A N/A N/A N/A N/A N/A 0.039±0.00 N/A N/A N/A 0.227±0.06 N/A 2.117±0.00
ENST00000370573 0.023±0.00 N/A N/A N/A N/A N/A N/A 0.043±0.00 N/A N/A N/A N/A N/A
ENST00000370576 N/A N/A N/A 0.470±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000414978 N/A 0.022±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000437564 N/A 0.117±0.00 N/A 1.669±0.00 0.069±0.00 0.079±0.00 0.042±0.00 0.433±0.00 0.017±0.00 N/A 0.481±0.32 0.034±0.00 3.506±0.94
ENST00000446225 N/A N/A N/A 0.941±0.23 N/A N/A N/A N/A 0.071±0.00 0.034±0.00 N/A N/A 9.982±0.00
ENST00000483690 N/A 0.066±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000519895 N/A N/A 0.317±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.018±0.00
ENST00000520602 N/A 0.023±0.00 N/A N/A N/A N/A 0.009±0.00 0.044±0.00 N/A N/A N/A N/A 0.542±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000PO CIL_0000PO_0002 CGP X:139530758-139708227
CIL_0000PN CIL_0000PN_0002 CGP X:139581770-139945276

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0005856 TAS cytoskeleton
GO:0007264 TAS small GTPase mediated signal transduction
GO:0016020 IEA membrane
GO:0016358 IEA dendrite development
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022895 mcf2a MCF.2 cell line derived transforming sequence a protein_coding Danio_rerio
ENSDARG00000056603 mcf2b MCF.2 cell line derived transforming sequence b protein_coding Danio_rerio
ENSMUSG00000031139 Mcf2 mcf.2 transforming sequence protein_coding Mus_musculus

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