C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 7
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102606 ARHGEF7 9606 + 13:111114559-111305737 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000218789 ARHGEF7-001 111153714-111305731 protein_coding
  ENST00000317133 ARHGEF7-008 111114619-111293436 protein_coding
  ENST00000375723 ARHGEF7-005 111205289-111295192 protein_coding
  ENST00000375736 ARHGEF7-007 111153738-111305731 protein_coding
  ENST00000375739 ARHGEF7-201 111115277-111295195 protein_coding
  ENST00000375741 ARHGEF7-202 111115277-111295195 protein_coding
  ENST00000422836 ARHGEF7-017 111115419-111116575 processed_transcript
  ENST00000426073 ARHGEF7-004 111186854-111305737 protein_coding
  ENST00000426768 ARHGEF7-009 111203060-111217885 protein_coding
  ENST00000449979 ARHGEF7-003 111115428-111217880 protein_coding
  ENST00000466143 ARHGEF7-013 111153689-111283226 protein_coding
  ENST00000467053 ARHGEF7-016 111184938-111217865 protein_coding
  ENST00000469877 ARHGEF7-012 111153689-111283298 nonsense_mediated_decay
  ENST00000478679 ARHGEF7-011 111241220-111292458 protein_coding
  ENST00000483189 ARHGEF7-010 111241145-111276031 processed_transcript
  ENST00000483540 ARHGEF7-014 111114559-111153962 processed_transcript
  ENST00000491688 ARHGEF7-006 111282828-111286236 processed_transcript
  ENST00000491775 ARHGEF7-015 111153647-111217800 protein_coding
  ENST00000544132 ARHGEF7-018 111275651-111281109 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000218789ENST00000375723ENST00000375736ENST00000375741ENST00000426073ENST00000466143
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000218789 N/A N/A N/A 6.709±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000375723 N/A N/A N/A 5.138±2.23 1.352±0.00 0.728±0.00 N/A N/A 1.025±0.00 N/A N/A 1.335±0.00 N/A 3.166±0.00
ENST00000375736 12.472±0.00 4.092±0.00 1.709±0.00 N/A 6.899±4.34 3.681±2.94 2.989±2.55 7.249±0.00 1.320±0.09 3.233±0.86 7.016±0.00 8.250±4.25 8.567±0.00 7.897±2.85
ENST00000375741 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.491±0.00
ENST00000426073 N/A N/A N/A 3.027±0.00 N/A N/A N/A N/A N/A 1.032±0.00 N/A N/A N/A N/A
ENST00000466143 N/A N/A N/A N/A N/A N/A 1.515±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007MP CIL_0007MP_0001 UCNEbase 13:110900477-111411201
CIL_00080T CIL_00080T_0001 VISTA 13:111084951-111685694
CIL_00012L CIL_00012L_0001 CGP 13:111114559-111344249

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007399 IEA nervous system development
GO:0010763 IDA positive regulation of fibroblast migration
GO:0019901 IPI protein kinase binding
GO:0030027 ISS lamellipodium
GO:0030032 ISS lamellipodium assembly
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0043005 IDA neuron projection
GO:0043025 IDA neuronal cell body
GO:0043065 IMP positive regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043547 IDA positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048041 IDA focal adhesion assembly
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway
GO:1900026 IMP positive regulation of substrate adhesion-dependent cell spreading
GO:2000394 IMP positive regulation of lamellipodium morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006299 arhgef7a Rho guanine nucleotide exchange factor (GEF) 7a protein_coding Danio_rerio
ENSDARG00000073848 arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b protein_coding Danio_rerio
ENSMUSG00000031511 Arhgef7 Rho guanine nucleotide exchange factor (GEF7) protein_coding Mus_musculus

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