C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rho guanine nucleotide exchange factor (GEF) 7
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000375736 ARHGEF7-007 ENSG00000102606 9606 + 13:111153738-111305731 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000375736
Transcript ID Adipose Adrenal Bladder Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000375736 12.472±0.00 4.092±0.00 1.709±0.00 6.899±4.34 3.681±2.94 2.989±2.55 7.249±0.00 1.320±0.09 3.233±0.86 7.016±0.00 8.250±4.25 8.567±0.00 7.897±2.85

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007MP CIL_0007MP_0001 UCNEbase 13:110900477-111411201
CIL_00080T CIL_00080T_0001 VISTA 13:111084951-111685694
CIL_00012L CIL_00012L_0001 CGP 13:111114559-111344249

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 IDA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007399 IEA nervous system development
GO:0010763 IDA positive regulation of fibroblast migration
GO:0019901 IPI protein kinase binding
GO:0030027 ISS lamellipodium
GO:0030032 ISS lamellipodium assembly
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042059 TAS negative regulation of epidermal growth factor receptor signaling pathway
GO:0043005 IDA neuron projection
GO:0043025 IDA neuronal cell body
GO:0043065 IMP positive regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043547 IDA positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048041 IDA focal adhesion assembly
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway
GO:1900026 IMP positive regulation of substrate adhesion-dependent cell spreading
GO:2000394 IMP positive regulation of lamellipodium morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000074856 Arhgef7-001 protein_coding Mus_musculus 0 2451
ENSMUST00000098938 Arhgef7-002 protein_coding Mus_musculus 0 2121
ENSMUST00000033908 Arhgef7-005 protein_coding Mus_musculus 0 2106
ENSMUST00000110909 Arhgef7-004 protein_coding Mus_musculus 0 2104
ENSMUST00000110904 Arhgef7-003 protein_coding Mus_musculus 0 1334
ENSMUST00000154204 Arhgef7-007 processed_transcript Mus_musculus 0 235
ENSMUST00000151225 Arhgef7-006 processed_transcript Mus_musculus 0 200

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