C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF7)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031511 Arhgef7 10090 + 8:11728105-11835219 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033908 Arhgef7-005 11728105-11823061 protein_coding
  ENSMUST00000074856 Arhgef7-001 11758354-11835219 protein_coding
  ENSMUST00000098938 Arhgef7-002 11758354-11835219 protein_coding
  ENSMUST00000110904 Arhgef7-003 11782641-11835219 protein_coding
  ENSMUST00000110909 Arhgef7-004 11728105-11827149 protein_coding
  ENSMUST00000151225 Arhgef7-006 11830238-11832300 processed_transcript
  ENSMUST00000154204 Arhgef7-007 11812362-11816345 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000074856ENSMUST00000098938ENSMUST00000110904ENSMUST00000110909
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000074856 11.149±4.17 14.459±1.44 10.312±1.22 11.864±2.40 11.098±4.99 11.934±3.17 17.232±2.25 17.415±3.26 4.144±1.33 19.323±6.93 7.624±2.79 17.272±4.99 12.443±5.25 5.380±1.61
ENSMUST00000098938 N/A N/A N/A 6.221±1.99 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.990±0.35
ENSMUST00000110904 3.196±0.32 N/A 3.154±0.04 6.234±2.06 2.875±0.00 N/A 4.210±0.58 N/A 1.053±0.00 6.183±0.44 1.686±0.04 5.985±1.24 2.390±0.00 7.348±0.00
ENSMUST00000110909 N/A N/A N/A 12.956±7.38 N/A N/A N/A N/A N/A N/A N/A 2.588±0.00 N/A 1.487±0.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00080T CIL_00080T_0002 VISTA 8:11596202-12196925
CIL_0007MP CIL_0007MP_0002 UCNEbase 8:11623645-11913000
CIL_00012L CIL_00012L_0002 CGP 8:11728105-11855761

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002244 IGI hematopoietic progenitor cell differentiation
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005925 IEA focal adhesion
GO:0007399 IEA nervous system development
GO:0010763 IEA positive regulation of fibroblast migration
GO:0019901 IPI protein kinase binding
GO:0030027 IDA lamellipodium
GO:0030032 IMP lamellipodium assembly
GO:0030054 IEA cell junction
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0043065 ISS positive regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043547 IEA positive regulation of GTPase activity
GO:0048041 IEA focal adhesion assembly
GO:1900026 IEA positive regulation of substrate adhesion-dependent cell spreading
GO:2000394 IEA positive regulation of lamellipodium morphogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006299 arhgef7a Rho guanine nucleotide exchange factor (GEF) 7a protein_coding Danio_rerio
ENSDARG00000073848 arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b protein_coding Danio_rerio
ENSG00000102606 ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 protein_coding Homo_sapiens

Loading