C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CCCTC-binding factor (zinc finger protein)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000102974 CTCF 9606 + 16:67562407-67639183 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264010 CTCF-001 67562407-67639183 protein_coding
  ENST00000401394 CTCF-002 67562407-67639183 protein_coding
  ENST00000566078 CTCF-003 67562538-67612146 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264010ENST00000401394ENST00000566078
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264010 10.008±0.00 11.076±0.00 1.609±0.00 6.291±3.21 6.010±2.73 7.691±4.10 4.460±3.73 5.577±3.62 3.431±0.13 6.045±1.70 5.370±4.28 10.583±9.00 7.619±0.55 7.662±2.98
ENST00000401394 N/A 4.485±0.00 N/A N/A 1.811±0.00 3.370±0.00 N/A 5.260±0.00 1.030±0.00 1.626±0.22 2.912±0.00 5.528±0.55 4.789±2.12 2.877±0.52
ENST00000566078 N/A N/A N/A N/A N/A N/A 0.307±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003LR CIL_0003LR_0002 CGP 16:67518418-67639183
CIL_0006LW CIL_0006LW_0002 CGP 16:67562407-67657569

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000775 IDA chromosome, centromeric region
GO:0000793 IDA condensed chromosome
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003714 TAS transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0006306 IEA DNA methylation
GO:0006349 IEA regulation of gene expression by genetic imprinting
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007059 IEA chromosome segregation
GO:0008270 TAS zinc ion binding
GO:0010216 IEA maintenance of DNA methylation
GO:0010628 IMP positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0016568 IEA chromatin modification
GO:0016584 IDA nucleosome positioning
GO:0031060 IEA regulation of histone methylation
GO:0035065 IEA regulation of histone acetylation
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0040030 IMP regulation of molecular function, epigenetic
GO:0043035 IDA chromatin insulator sequence binding
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding
GO:0070602 NAS regulation of centromeric sister chromatid cohesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056621 ctcf CCCTC-binding factor (zinc finger protein) protein_coding Danio_rerio
ENSMUSG00000005698 Ctcf CCCTC-binding factor protein_coding Mus_musculus

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