C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: collagen, type I, alpha 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108821 COL1A1 9606 - 17:50183289-50201632 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000225964 COL1A1-001 50183289-50201632 protein_coding
  ENST00000463440 COL1A1-005 50193486-50194352 retained_intron
  ENST00000471344 COL1A1-006 50193550-50195665 retained_intron
  ENST00000474644 COL1A1-002 50199278-50201632 retained_intron
  ENST00000476387 COL1A1-007 50190909-50194058 retained_intron
  ENST00000485870 COL1A1-004 50196079-50196595 retained_intron
  ENST00000486572 COL1A1-009 50187607-50188554 retained_intron
  ENST00000494334 COL1A1-008 50190309-50190924 retained_intron
  ENST00000495677 COL1A1-003 50196520-50198702 retained_intron
  ENST00000504289 COL1A1-014 50191866-50192439 retained_intron
  ENST00000507689 COL1A1-013 50199289-50200191 protein_coding
  ENST00000510710 COL1A1-018 50185844-50187122 retained_intron
  ENST00000511732 COL1A1-016 50187892-50188784 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000225964ENST00000474644ENST00000476387ENST00000510710
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000225964 23.475±0.00 75.399±0.00 1.109±0.00 0.347±0.30 68.980±35.16 8.311±0.00 4.391±3.52 13.830±3.10 12.012±10.65 1.122±0.73 280.501±357.09 379.113±62.41 52.524±37.34
ENST00000474644 N/A N/A N/A N/A 60.357±0.00 17.682±0.00 3.852±0.00 47.494±0.00 10.120±0.00 11.996±0.00 97.885±0.00 N/A N/A
ENST00000476387 N/A N/A N/A 0.072±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000510710 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.106±0.00 319.172±0.00 923.092±0.00 23.877±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088W CIL_00088W_0001 VISTA 17:49956976-50560219
CIL_0004X4 CIL_0004X4_0002 CGP 17:50164214-50201632

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IMP skeletal system development
GO:0001503 IEA ossification
GO:0001568 IMP blood vessel development
GO:0001649 IEA osteoblast differentiation
GO:0001957 IEA intramembranous ossification
GO:0001958 IEA endochondral ossification
GO:0005201 IEA extracellular matrix structural constituent
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005581 IEA collagen trimer
GO:0005584 IMP collagen type I trimer
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005788 TAS endoplasmic reticulum lumen
GO:0005794 IEA Golgi apparatus
GO:0007584 IEA response to nutrient
GO:0007596 TAS blood coagulation
GO:0007601 IMP visual perception
GO:0007605 IMP sensory perception of sound
GO:0009612 IEA response to mechanical stimulus
GO:0010718 IDA positive regulation of epithelial to mesenchymal transition
GO:0010812 IEA negative regulation of cell-substrate adhesion
GO:0015031 IEA protein transport
GO:0022617 TAS extracellular matrix disassembly
GO:0030141 IEA secretory granule
GO:0030168 TAS platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030199 IMP collagen fibril organization
GO:0030335 IDA positive regulation of cell migration
GO:0030574 TAS collagen catabolic process
GO:0031012 IDA extracellular matrix
GO:0031667 IEA response to nutrient levels
GO:0031960 IEA response to corticosteroid
GO:0032355 IEA response to estradiol
GO:0032964 IMP collagen biosynthetic process
GO:0034504 IDA protein localization to nucleus
GO:0034505 IMP tooth mineralization
GO:0042060 IEA wound healing
GO:0042493 IEA response to drug
GO:0042542 IEA response to hydrogen peroxide
GO:0042802 IDA identical protein binding
GO:0043434 IEA response to peptide hormone
GO:0043588 IEA skin development
GO:0043589 IMP skin morphogenesis
GO:0044344 IEA cellular response to fibroblast growth factor stimulus
GO:0044691 IEA tooth eruption
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding
GO:0048407 IDA platelet-derived growth factor binding
GO:0048545 IEA response to steroid hormone
GO:0048705 IEA skeletal system morphogenesis
GO:0048706 IMP embryonic skeletal system development
GO:0050900 TAS leukocyte migration
GO:0051591 IEA response to cAMP
GO:0055093 IEA response to hyperoxia
GO:0060325 IEA face morphogenesis
GO:0060346 IEA bone trabecula formation
GO:0060351 IEA cartilage development involved in endochondral bone morphogenesis
GO:0070208 IEA protein heterotrimerization
GO:0071230 IEA cellular response to amino acid stimulus
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071300 IEA cellular response to retinoic acid
GO:0071306 IEA cellular response to vitamin E
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071364 IEA cellular response to epidermal growth factor stimulus
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0090263 IDA positive regulation of canonical Wnt signaling pathway
GO:1902617 IEA response to fluoride
GO:1902618 IEA cellular response to fluoride

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012405 col1a1a collagen, type I, alpha 1a protein_coding Danio_rerio
ENSDARG00000035809 col1a1b collagen, type I, alpha 1b protein_coding Danio_rerio
ENSMUSG00000001506 Col1a1 collagen, type I, alpha 1 protein_coding Mus_musculus

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