C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transient receptor potential cation channel, subfamily V, member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000111199 TRPV4 9606 - 12:109783085-109833401 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261740 TRPV4-001 109783087-109833401 protein_coding
  ENST00000418703 TRPV4-006 109783085-109814891 protein_coding
  ENST00000536570 TRPV4-008 109814701-109832735 processed_transcript
  ENST00000536838 TRPV4-005 109783621-109814796 protein_coding
  ENST00000537083 TRPV4-003 109783621-109814796 protein_coding
  ENST00000538125 TRPV4-007 109783558-109833401 nonsense_mediated_decay
  ENST00000541794 TRPV4-004 109783621-109814796 protein_coding
  ENST00000544971 TRPV4-002 109783621-109814796 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000261740ENST00000418703ENST00000536570ENST00000536838ENST00000537083ENST00000538125ENST00000541794ENST00000544971
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000261740 0.178±0.00 N/A 0.082±0.00 N/A 0.042±0.00 0.093±0.00 3.392±0.00 0.382±0.00 N/A 0.579±0.14 3.630±1.86 N/A
ENST00000418703 N/A N/A N/A N/A N/A N/A N/A N/A 1.148±0.00 N/A N/A N/A
ENST00000536570 N/A N/A N/A 0.230±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000536838 N/A N/A N/A N/A N/A 0.115±0.00 N/A N/A N/A 0.298±0.04 1.790±0.98 N/A
ENST00000537083 N/A N/A 0.160±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000538125 N/A 0.394±0.00 N/A 0.212±0.00 N/A N/A 0.211±0.00 N/A N/A N/A N/A N/A
ENST00000541794 N/A 3.030±0.00 0.147±0.00 N/A N/A N/A 0.463±0.00 N/A N/A N/A 1.926±0.00 N/A
ENST00000544971 N/A N/A 0.077±0.00 N/A 0.076±0.00 N/A N/A 0.133±0.00 N/A N/A N/A 0.422±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001JO CIL_0001JO_0002 CGP 12:109714228-109833401
CIL_00062E CIL_00062E_0002 CGP 12:109783085-109880488

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003779 ISS actin binding
GO:0005034 IEA osmosensor activity
GO:0005080 ISS protein kinase C binding
GO:0005216 IEA ion channel activity
GO:0005261 IDA cation channel activity
GO:0005262 IDA calcium channel activity
GO:0005515 IEA protein binding
GO:0005516 IMP calmodulin binding
GO:0005524 IEA ATP binding
GO:0005881 ISS cytoplasmic microtubule
GO:0005886 ISS plasma membrane
GO:0005912 ISS adherens junction
GO:0005925 ISS focal adhesion
GO:0005929 IEA cilium
GO:0006811 IEA ion transport
GO:0006816 NAS calcium ion transport
GO:0006874 IDA cellular calcium ion homeostasis
GO:0006884 TAS cell volume homeostasis
GO:0006970 IEA response to osmotic stress
GO:0006971 IEA hypotonic response
GO:0007015 ISS actin filament organization
GO:0007043 ISS cell-cell junction assembly
GO:0007204 IDA positive regulation of cytosolic calcium ion concentration
GO:0007231 ISS osmosensory signaling pathway
GO:0008017 ISS microtubule binding
GO:0008219 IEA cell death
GO:0009612 TAS response to mechanical stimulus
GO:0009986 IEA cell surface
GO:0010977 ISS negative regulation of neuron projection development
GO:0016020 IEA membrane
GO:0016021 IEA:NAS integral component of membrane
GO:0019901 IPI protein kinase binding
GO:0030027 ISS lamellipodium
GO:0030103 IEA vasopressin secretion
GO:0030175 ISS filopodium
GO:0030426 ISS growth cone
GO:0030864 ISS cortical actin cytoskeleton
GO:0031117 ISS positive regulation of microtubule depolymerization
GO:0031410 IEA cytoplasmic vesicle
GO:0031532 ISS actin cytoskeleton reorganization
GO:0032587 ISS ruffle membrane
GO:0034220 TAS ion transmembrane transport
GO:0034605 ISS cellular response to heat
GO:0042169 ISS SH2 domain binding
GO:0042538 IEA hyperosmotic salinity response
GO:0043014 ISS alpha-tubulin binding
GO:0043622 ISS cortical microtubule organization
GO:0046785 ISS microtubule polymerization
GO:0047484 IEA regulation of response to osmotic stress
GO:0048487 ISS beta-tubulin binding
GO:0051015 ISS actin filament binding
GO:0055085 TAS:IEA transmembrane transport
GO:0070509 ISS calcium ion import
GO:0070588 TAS calcium ion transmembrane transport
GO:0071470 ISS cellular response to osmotic stress
GO:0071476 ISS cellular hypotonic response

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061941 trpv4 transient receptor potential cation channel, subfamily V, member 4 protein_coding Danio_rerio
ENSMUSG00000014158 Trpv4 transient receptor potential cation channel, subfamily V, member 4 protein_coding Mus_musculus

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