C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SMAD family member 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113658 SMAD5 9606 + 5:136132845-136188747 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000506223 SMAD5-008 136133823-136154002 protein_coding
  ENST00000507118 SMAD5-002 136132847-136154144 protein_coding
  ENST00000507245 SMAD5-009 136147420-136153681 retained_intron
  ENST00000507637 SMAD5-010 136160986-136172829 protein_coding
  ENST00000509297 SMAD5-004 136133353-136153763 protein_coding
  ENST00000509962 SMAD5-007 136133224-136153729 processed_transcript
  ENST00000511116 SMAD5-003 136132847-136154163 protein_coding
  ENST00000513418 SMAD5-012 136174469-136188747 nonsense_mediated_decay
  ENST00000514777 SMAD5-011 136132904-136177386 processed_transcript
  ENST00000515005 SMAD5-005 136133353-136153763 protein_coding
  ENST00000545279 SMAD5-001 136132845-136182732 protein_coding
  ENST00000545620 SMAD5-201 136132847-136182734 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000506223ENST00000507118ENST00000507637ENST00000545279ENST00000545620
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000506223 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.197±0.00 N/A N/A N/A
ENST00000507118 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.561±0.00 N/A N/A
ENST00000507637 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.624±0.00 N/A N/A N/A
ENST00000545279 2.369±0.00 0.690±0.00 3.048±0.00 1.377±0.00 3.155±1.39 2.291±1.54 1.502±0.58 1.297±0.00 0.859±0.00 5.511±0.00 0.866±0.00 3.731±2.65 1.789±0.52 1.837±0.00
ENST00000545620 5.701±0.00 4.945±0.00 N/A 2.472±0.12 3.798±1.03 3.626±2.61 2.018±1.23 6.490±0.00 5.256±2.99 4.783±0.00 1.584±0.92 3.753±2.44 3.573±0.94 4.449±2.89

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005P2 CIL_0005P2_0001 CGP 5:136028895-136188747
CIL_0005P3 CIL_0005P3_0001 CGP 5:136132845-136365537

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001503 IEA ossification
GO:0001657 IEA ureteric bud development
GO:0001880 IEA Mullerian duct regression
GO:0002051 IEA osteoblast fate commitment
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005057 NAS receptor signaling protein activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0007165 NAS signal transduction
GO:0007179 IEA transforming growth factor beta receptor signaling pathway
GO:0007281 IEA germ cell development
GO:0009880 ISS embryonic pattern specification
GO:0016021 NAS integral component of membrane
GO:0030218 IEA erythrocyte differentiation
GO:0030509 ISS BMP signaling pathway
GO:0030618 TAS transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625 IPI ubiquitin protein ligase binding
GO:0035556 TAS intracellular signal transduction
GO:0043234 IDA protein complex
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045893 NAS positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0051216 IEA cartilage development
GO:0060048 IEA cardiac muscle contraction
GO:0060348 IEA bone development
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071773 ISS cellular response to BMP stimulus
GO:1901522 ISS positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000021540 Smad5 SMAD family member 5 protein_coding Mus_musculus

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