C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adrenoceptor alpha 1A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120907 ADRA1A 9606 - 8:26748150-26867273 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000276393 ADRA1A-003 26769705-26865405 protein_coding
  ENST00000354550 ADRA1A-002 26765854-26865169 protein_coding
  ENST00000380572 ADRA1A-005 26779053-26865405 protein_coding
  ENST00000380573 ADRA1A-008 26770026-26867273 protein_coding
  ENST00000380582 ADRA1A-001 26756396-26865405 protein_coding
  ENST00000380586 ADRA1A-004 26748150-26865405 protein_coding
  ENST00000518621 ADRA1A-011 26770210-26854574 processed_transcript
  ENST00000518810 ADRA1A-010 26853730-26854651 processed_transcript
  ENST00000519096 ADRA1A-007 26748150-26865405 nonsense_mediated_decay
  ENST00000519229 ADRA1A-009 26756560-26864976 protein_coding
  ENST00000521711 ADRA1A-006 26756396-26865405 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENST00000276393ENST00000354550ENST00000380572ENST00000380573ENST00000380582ENST00000380586ENST00000518621ENST00000518810ENST00000519096ENST00000519229ENST00000521711
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000276393 0.292±0.00 0.237±0.00 N/A N/A 0.640±0.00 N/A 0.067±0.00 N/A 0.858±0.11 N/A 0.111±0.00 N/A 0.152±0.00
ENST00000354550 0.406±0.00 0.351±0.00 N/A N/A 0.304±0.00 N/A N/A N/A 0.374±0.00 N/A 0.164±0.00 N/A 0.261±0.00
ENST00000380572 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.114±0.00 0.050±0.00 N/A N/A
ENST00000380573 N/A N/A 0.065±0.00 N/A 0.321±0.00 0.030±0.00 8.224±8.07 0.518±0.00 N/A N/A 0.278±0.25 N/A N/A
ENST00000380582 N/A N/A N/A 1.360±0.00 3.482±0.00 N/A N/A N/A N/A N/A 0.033±0.00 N/A N/A
ENST00000380586 N/A N/A N/A N/A N/A 0.033±0.00 N/A N/A N/A N/A 0.108±0.00 0.032±0.00 0.228±0.06
ENST00000518621 N/A N/A N/A N/A N/A 0.701±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000518810 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.229±0.00
ENST00000519096 N/A N/A N/A N/A N/A N/A 0.147±0.00 N/A N/A N/A N/A N/A N/A
ENST00000519229 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.028±0.00 N/A N/A
ENST00000521711 N/A N/A 0.081±0.00 N/A N/A 0.345±0.00 0.084±0.00 N/A N/A N/A 0.069±0.00 N/A 0.309±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005TP CIL_0005TP_0002 CGP 8:26514275-26867273

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001985 IEA negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 IEA norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 IEA positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 IEA positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 IEA positive regulation of systemic arterial blood pressure
GO:0004930 IEA G-protein coupled receptor activity
GO:0004937 ISS alpha1-adrenergic receptor activity
GO:0005634 IDA nucleus
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006915 TAS apoptotic process
GO:0006939 TAS smooth muscle contraction
GO:0007165 TAS signal transduction
GO:0007186 TAS:IEA G-protein coupled receptor signaling pathway
GO:0007200 IEA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 ISS activation of phospholipase C activity
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0007267 TAS cell-cell signaling
GO:0007512 IEA adult heart development
GO:0007568 ISS aging
GO:0008285 TAS negative regulation of cell proliferation
GO:0009725 ISS response to hormone
GO:0010460 IEA positive regulation of heart rate
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016049 IEA cell growth
GO:0019229 IEA regulation of vasoconstriction
GO:0030018 IEA Z disc
GO:0030315 IEA T-tubule
GO:0031965 IDA nuclear membrane
GO:0032229 ISS negative regulation of synaptic transmission, GABAergic
GO:0032230 IEA positive regulation of synaptic transmission, GABAergic
GO:0035024 ISS negative regulation of Rho protein signal transduction
GO:0035265 IEA organ growth
GO:0035556 TAS intracellular signal transduction
GO:0042493 ISS response to drug
GO:0043410 IDA positive regulation of MAPK cascade
GO:0045760 ISS positive regulation of action potential
GO:0045907 ISS positive regulation of vasoconstriction
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046982 IDA protein heterodimerization activity
GO:0055117 IEA regulation of cardiac muscle contraction
GO:0060073 IEA micturition
GO:0060402 ISS calcium ion transport into cytosol
GO:0060452 ISS positive regulation of cardiac muscle contraction
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071875 IEA adrenergic receptor signaling pathway
GO:0090037 ISS positive regulation of protein kinase C signaling
GO:0097195 IEA pilomotor reflex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027638 adra1ab adrenergic, alpha-1Ab, receptor protein_coding Danio_rerio
ENSDARG00000028725 ADRA1A (2 of 2) adrenoceptor alpha 1A protein_coding Danio_rerio
ENSMUSG00000045875 Adra1a adrenergic receptor, alpha 1a protein_coding Mus_musculus

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