C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: adrenoceptor alpha 1A
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000380586 ADRA1A-004 ENSG00000120907 9606 - 8:26748150-26865405 protein_coding

Homo sapiens EnsemblGRCh38

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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; ColonOvaryPlacentaTestisENST00000380586
Transcript ID Colon Ovary Placenta Testis
ENST00000380586 0.033±0.00 0.108±0.00 0.032±0.00 0.228±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005TP CIL_0005TP_0002 CGP 8:26514275-26867273

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001985 IEA negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 IEA norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 IEA positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 IEA positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 IEA positive regulation of systemic arterial blood pressure
GO:0004930 IEA G-protein coupled receptor activity
GO:0004937 ISS alpha1-adrenergic receptor activity
GO:0005634 IDA nucleus
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006915 TAS apoptotic process
GO:0006939 TAS smooth muscle contraction
GO:0007165 TAS signal transduction
GO:0007186 TAS:IEA G-protein coupled receptor signaling pathway
GO:0007200 IEA phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 ISS activation of phospholipase C activity
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0007267 TAS cell-cell signaling
GO:0007512 IEA adult heart development
GO:0007568 ISS aging
GO:0008285 TAS negative regulation of cell proliferation
GO:0009725 ISS response to hormone
GO:0010460 IEA positive regulation of heart rate
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016049 IEA cell growth
GO:0030018 IEA Z disc
GO:0030315 IEA T-tubule
GO:0031965 IDA nuclear membrane
GO:0032229 ISS negative regulation of synaptic transmission, GABAergic
GO:0032230 IEA positive regulation of synaptic transmission, GABAergic
GO:0035024 ISS negative regulation of Rho protein signal transduction
GO:0035265 IEA organ growth
GO:0035556 TAS intracellular signal transduction
GO:0042493 ISS response to drug
GO:0043410 IDA positive regulation of MAPK cascade
GO:0045760 ISS positive regulation of action potential
GO:0045907 ISS positive regulation of vasoconstriction
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046982 IDA protein heterodimerization activity
GO:0060073 IEA micturition
GO:0060402 ISS calcium ion transport into cytosol
GO:0060452 ISS positive regulation of cardiac muscle contraction
GO:0070374 ISS positive regulation of ERK1 and ERK2 cascade
GO:0071875 IEA adrenergic receptor signaling pathway
GO:0090037 ISS positive regulation of protein kinase C signaling
GO:0097195 IEA pilomotor reflex

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000159068 Adra1a-004 protein_coding Mus_musculus 0 1509
ENSMUST00000054661 Adra1a-002 protein_coding Mus_musculus 0 1509
ENSMUST00000159365 Adra1a-001 protein_coding Mus_musculus 0 1509
ENSMUST00000161339 Adra1a-003 protein_coding Mus_musculus 0 1456
ENSMUST00000160647 Adra1a-005 retained_intron Mus_musculus 0 1086

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