C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endothelin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124205 EDN3 9606 + 20:59300427-59325992 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311585 EDN3-002 59300443-59325992 protein_coding
  ENST00000337938 EDN3-001 59300427-59325992 protein_coding
  ENST00000371025 EDN3-004 59300618-59324746 protein_coding
  ENST00000371028 EDN3-201 59300444-59325991 protein_coding
  ENST00000395654 EDN3-003 59300703-59325992 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000311585ENST00000337938ENST00000371025ENST00000371028ENST00000395654
Transcript ID Adrenal Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000311585 N/A N/A 0.371±0.00 1.593±0.00 N/A N/A N/A N/A 0.282±0.19 N/A 0.339±0.00
ENST00000337938 N/A 0.755±0.00 0.502±0.15 N/A N/A N/A 0.035±0.00 N/A 0.171±0.00 0.159±0.00 N/A
ENST00000371025 N/A N/A N/A N/A N/A N/A 0.100±0.01 0.322±0.00 N/A N/A N/A
ENST00000371028 N/A 0.401±0.00 0.089±0.00 2.357±0.00 0.013±0.00 N/A N/A 0.513±0.00 0.125±0.00 0.439±0.46 0.506±0.20
ENST00000395654 0.058±0.00 0.255±0.04 N/A 0.390±0.00 N/A 0.269±0.00 N/A N/A N/A N/A 0.261±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00093L CIL_00093L_0001 VISTA 20:59111478-59715059
CIL_00074T CIL_00074T_0001 CGP 20:59191020-59325992

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001755 IEA neural crest cell migration
GO:0002690 IDA positive regulation of leukocyte chemotaxis
GO:0003100 IDA regulation of systemic arterial blood pressure by endothelin
GO:0005102 TAS receptor binding
GO:0005179 IDA hormone activity
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0006874 IEA cellular calcium ion homeostasis
GO:0007165 TAS signal transduction
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007267 TAS cell-cell signaling
GO:0007275 TAS multicellular organismal development
GO:0008015 TAS blood circulation
GO:0008284 IEA positive regulation of cell proliferation
GO:0010460 IDA positive regulation of heart rate
GO:0010961 IEA cellular magnesium ion homeostasis
GO:0014826 IDA vein smooth muscle contraction
GO:0019229 IEA regulation of vasoconstriction
GO:0030072 IDA peptide hormone secretion
GO:0030182 IEA neuron differentiation
GO:0030318 IEA melanocyte differentiation
GO:0030334 IEA regulation of cell migration
GO:0030593 IDA neutrophil chemotaxis
GO:0042310 IDA vasoconstriction
GO:0043406 IDA positive regulation of MAP kinase activity
GO:0045840 IDA positive regulation of mitosis
GO:0046887 IDA positive regulation of hormone secretion
GO:0048016 IDA inositol phosphate-mediated signaling
GO:0048070 IEA regulation of developmental pigmentation
GO:1901381 IEA positive regulation of potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070925 endothelin 3 protein_coding Danio_rerio
ENSDARG00000086669 edn3b endothelin 3b protein_coding Danio_rerio
ENSMUSG00000027524 Edn3 endothelin 3 protein_coding Mus_musculus

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