C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK2 homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125820 NKX2-2 9606 - 20:21511010-21514026 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000377142 NKX2-2-001 21511010-21514026 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainColonTestisENST00000377142
Transcript ID Adipose Adrenal Brain Colon Testis
ENST00000377142 0.045±0.00 0.011±0.00 1.116±0.64 0.061±0.00 0.042±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097L CIL_00097L_0001 VISTA 20:20934152-21536594
CIL_0008VN CIL_0008VN_0001 VISTA 20:21207913-21809383
CIL_0006WU CIL_0006WU_0001 CGP 20:21395367-21514026
CIL_0001U0 CIL_0001U0_0001 CGP 20:21511010-21718486

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001159 ISS core promoter proximal region DNA binding
GO:0003323 IEA type B pancreatic cell development
GO:0003326 IEA pancreatic A cell fate commitment
GO:0003327 IEA type B pancreatic cell fate commitment
GO:0003329 IEA pancreatic PP cell fate commitment
GO:0003677 IEA DNA binding
GO:0003682 ISS chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 ISS transcription coactivator activity
GO:0005515 IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007224 IEA smoothened signaling pathway
GO:0007399 IEA nervous system development
GO:0007420 TAS brain development
GO:0008134 IEA transcription factor binding
GO:0009749 IEA response to glucose
GO:0010628 IEA positive regulation of gene expression
GO:0014003 IEA oligodendrocyte development
GO:0014070 IEA response to organic cyclic compound
GO:0021522 IEA spinal cord motor neuron differentiation
GO:0021529 IEA spinal cord oligodendrocyte cell differentiation
GO:0021530 IEA spinal cord oligodendrocyte cell fate specification
GO:0021554 IEA optic nerve development
GO:0030154 IEA cell differentiation
GO:0031018 TAS endocrine pancreas development
GO:0032570 IEA response to progesterone
GO:0043565 IEA sequence-specific DNA binding
GO:0045595 IEA regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045665 IEA negative regulation of neuron differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048468 IEA cell development
GO:0048565 IEA digestive tract development
GO:0048665 IEA neuron fate specification
GO:0048708 IEA astrocyte differentiation
GO:0048714 IEA positive regulation of oligodendrocyte differentiation
GO:0051091 ISS positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060580 IEA ventral spinal cord interneuron fate determination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053298 nkx2.2a NK2 transcription factor related 2a protein_coding Danio_rerio
ENSMUSG00000027434 Nkx2-2 NK2 homeobox 2 protein_coding Mus_musculus

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