C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK2 homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027434 Nkx2-2 10090 - 2:147177546-147194243 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067075 Nkx2-2-002 147183083-147186404 protein_coding
  ENSMUST00000109969 Nkx2-2-003 147186305-147194243 processed_transcript
  ENSMUST00000109970 Nkx2-2-001 147177546-147186101 protein_coding
  ENSMUST00000172627 Nkx2-2-004 147186382-147194242 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonLiverLungMusclePlacentaTestisENSMUST00000067075ENSMUST00000109969ENSMUST00000109970
Transcript ID Brain Colon Liver Lung Muscle Placenta Testis
ENSMUST00000067075 1.254±0.57 0.212±0.09 0.013±0.01 0.013±0.00 N/A 0.006±0.00 0.014±0.00
ENSMUST00000109969 N/A N/A N/A 0.152±0.00 N/A N/A N/A
ENSMUST00000109970 1.244±0.47 0.801±0.26 N/A N/A 0.062±0.00 0.075±0.03 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00097L CIL_00097L_0002 VISTA 2:146657766-147260813
CIL_0008VN CIL_0008VN_0002 VISTA 2:146880290-147481581
CIL_0006WU CIL_0006WU_0002 CGP 2:147083316-147194243
CIL_0001U0 CIL_0001U0_0002 CGP 2:147177546-147393295

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001159 IDA core promoter proximal region DNA binding
GO:0003323 IMP type B pancreatic cell development
GO:0003326 IMP pancreatic A cell fate commitment
GO:0003327 IMP type B pancreatic cell fate commitment
GO:0003329 IGI pancreatic PP cell fate commitment
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0007224 IDA smoothened signaling pathway
GO:0007399 IDA nervous system development
GO:0008134 IPI transcription factor binding
GO:0009749 IEA response to glucose
GO:0010628 IDA positive regulation of gene expression
GO:0014003 IMP oligodendrocyte development
GO:0014070 IEA response to organic cyclic compound
GO:0021522 IMP spinal cord motor neuron differentiation
GO:0021529 IMP spinal cord oligodendrocyte cell differentiation
GO:0021530 IDA spinal cord oligodendrocyte cell fate specification
GO:0021554 IEA optic nerve development
GO:0030154 IMP cell differentiation
GO:0031018 IMP endocrine pancreas development
GO:0032570 IEA response to progesterone
GO:0043565 IDA sequence-specific DNA binding
GO:0045595 IMP regulation of cell differentiation
GO:0045597 IMP positive regulation of cell differentiation
GO:0045665 IMP negative regulation of neuron differentiation
GO:0045666 IMP positive regulation of neuron differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048468 IMP cell development
GO:0048565 IMP digestive tract development
GO:0048665 IGI neuron fate specification
GO:0048708 IMP astrocyte differentiation
GO:0048714 IGI positive regulation of oligodendrocyte differentiation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060580 IMP ventral spinal cord interneuron fate determination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053298 nkx2.2a NK2 transcription factor related 2a protein_coding Danio_rerio
ENSG00000125820 NKX2-2 NK2 homeobox 2 protein_coding Homo_sapiens

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