C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129675 ARHGEF6 9606 - X:136665547-136782088 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000250617 ARHGEF6-001 136665547-136782088 protein_coding
  ENST00000370620 ARHGEF6-003 136665547-136767343 protein_coding
  ENST00000370622 ARHGEF6-002 136665547-136768627 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000250617ENST00000370620ENST00000370622
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000250617 4.583±0.00 N/A 0.724±0.00 4.217±0.23 1.381±0.00 0.472±0.00 N/A 2.609±0.00 4.755±0.00 2.276±1.72 0.878±0.27 2.054±0.68 0.220±0.00
ENST00000370620 16.977±0.00 8.238±0.00 5.389±3.17 13.477±10.73 3.571±2.80 6.930±4.71 3.216±0.00 1.355±0.48 4.865±3.62 5.217±0.31 3.645±2.31 9.247±1.96 3.824±1.47
ENST00000370622 N/A N/A N/A N/A N/A N/A 0.382±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000JT CIL_0000JT_0001 CGP X:136648193-136782088
CIL_0000PR CIL_0000PR_0002 CGP X:136665547-136880764

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 NAS:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 NAS GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IC intracellular
GO:0005829 TAS cytosol
GO:0005911 IEA cell-cell junction
GO:0006915 NAS apoptotic process
GO:0007254 NAS JNK cascade
GO:0007264 TAS small GTPase mediated signal transduction
GO:0030027 ISS lamellipodium
GO:0030032 ISS lamellipodium assembly
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0034329 TAS cell junction assembly
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006683 arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 protein_coding Danio_rerio
ENSMUSG00000031133 Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 protein_coding Mus_musculus

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