C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031133 Arhgef6 10090 - X:57231485-57338729 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033468 Arhgef6-001 57231485-57338729 protein_coding
  ENSMUST00000114735 Arhgef6-003 57233440-57281594 protein_coding
  ENSMUST00000134028 Arhgef6-002 57272228-57326601 retained_intron
  ENSMUST00000135098 Arhgef6-005 57335904-57338506 retained_intron
  ENSMUST00000151768 Arhgef6-004 57231485-57240889 retained_intron
  ENSMUST00000175636 Arhgef6-007 57298512-57300859 processed_transcript
  ENSMUST00000175900 Arhgef6-008 57239230-57251344 protein_coding
  ENSMUST00000176986 Arhgef6-006 57248987-57326599 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033468ENSMUST00000114735ENSMUST00000151768ENSMUST00000175636ENSMUST00000175900ENSMUST00000176986
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033468 2.005±0.75 N/A 1.044±0.26 0.299±0.05 3.563±1.58 0.481±0.16 1.713±0.00 1.092±0.16 0.644±0.38 3.410±0.77 2.840±0.00 2.177±1.26 9.436±1.31 0.561±0.08
ENSMUST00000114735 N/A N/A N/A 2.323±0.00 N/A N/A N/A N/A N/A N/A N/A 10.094±0.00 125.994±3.98 10.219±6.43
ENSMUST00000151768 6.119±2.07 4.625±1.73 2.547±1.14 1.021±0.65 13.459±7.12 1.872±0.35 8.550±1.40 2.976±0.99 1.050±0.47 5.725±1.95 2.649±0.00 5.544±2.01 26.251±4.62 N/A
ENSMUST00000175636 N/A N/A N/A 1.856±0.00 N/A N/A N/A N/A 1.259±0.00 N/A N/A N/A N/A N/A
ENSMUST00000175900 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.147±0.89
ENSMUST00000176986 N/A 1.943±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 5.185±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000JT CIL_0000JT_0002 CGP X:57212143-57338729
CIL_0000PR CIL_0000PR_0003 CGP X:57231485-57393036

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005911 IDA cell-cell junction
GO:0030027 IDA lamellipodium
GO:0030032 IMP lamellipodium assembly
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035556 IEA intracellular signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006683 arhgef6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 protein_coding Danio_rerio
ENSG00000129675 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 protein_coding Homo_sapiens

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