C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000370620 ARHGEF6-003 ENSG00000129675 9606 - X:136665547-136767343 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000370620
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000370620 16.977±0.00 8.238±0.00 5.389±3.17 13.477±10.73 3.571±2.80 6.930±4.71 3.216±0.00 1.355±0.48 4.865±3.62 5.217±0.31 3.645±2.31 9.247±1.96 3.824±1.47

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000JT CIL_0000JT_0001 CGP X:136648193-136782088
CIL_0000PR CIL_0000PR_0002 CGP X:136665547-136880764

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 NAS:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 NAS GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IC intracellular
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0007254 NAS JNK cascade
GO:0007264 TAS small GTPase mediated signal transduction
GO:0030027 ISS lamellipodium
GO:0030032 ISS lamellipodium assembly
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0034329 TAS cell junction assembly
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000033468 Arhgef6-001 protein_coding Mus_musculus 0 2549
ENSMUST00000176986 Arhgef6-006 protein_coding Mus_musculus 0 1489
ENSMUST00000114735 Arhgef6-003 protein_coding Mus_musculus 0 1214
ENSMUST00000134028 Arhgef6-002 retained_intron Mus_musculus 0 1077
ENSMUST00000175900 Arhgef6-008 protein_coding Mus_musculus 0 841
ENSMUST00000151768 Arhgef6-004 retained_intron Mus_musculus 0 305
ENSMUST00000175636 Arhgef6-007 processed_transcript Mus_musculus 0 298

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