C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000370622 ARHGEF6-002 ENSG00000129675 9606 - X:136665547-136768627 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; KidneyENST00000370622
Transcript ID Kidney
ENST00000370622 0.382±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000JT CIL_0000JT_0001 CGP X:136648193-136782088
CIL_0000PR CIL_0000PR_0002 CGP X:136665547-136880764

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005089 NAS:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 NAS GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IC intracellular
GO:0005829 TAS cytosol
GO:0006915 NAS apoptotic process
GO:0007254 NAS JNK cascade
GO:0007264 TAS small GTPase mediated signal transduction
GO:0030027 ISS lamellipodium
GO:0030032 ISS lamellipodium assembly
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0034329 TAS cell junction assembly
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000033468 Arhgef6-001 protein_coding Mus_musculus 0 2549
ENSMUST00000176986 Arhgef6-006 protein_coding Mus_musculus 0 1432
ENSMUST00000114735 Arhgef6-003 protein_coding Mus_musculus 0 1214
ENSMUST00000134028 Arhgef6-002 retained_intron Mus_musculus 0 1020
ENSMUST00000175900 Arhgef6-008 protein_coding Mus_musculus 0 841
ENSMUST00000151768 Arhgef6-004 retained_intron Mus_musculus 0 305
ENSMUST00000175636 Arhgef6-007 processed_transcript Mus_musculus 0 298

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