C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: low density lipoprotein receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000130164 LDLR 9606 + 19:11089362-11133816 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000252444 LDLR-004 11090599-11133816 protein_coding
  ENST00000455727 LDLR-007 11089463-11131484 protein_coding
  ENST00000535915 LDLR-001 11089463-11131538 protein_coding
  ENST00000545707 LDLR-006 11089463-11131610 protein_coding
  ENST00000557933 LDLR-012 11089462-11131525 protein_coding
  ENST00000557958 LDLR-009 11089463-11104268 retained_intron
  ENST00000558013 LDLR-002 11089478-11131812 protein_coding
  ENST00000558518 LDLR-003 11089362-11132163 protein_coding
  ENST00000558528 LDLR-010 11106356-11107515 retained_intron
  ENST00000559340 LDLR-015 11113371-11120406 nonsense_mediated_decay
  ENST00000560173 LDLR-013 11110713-11113481 retained_intron
  ENST00000560467 LDLR-011 11105307-11113624 protein_coding
  ENST00000560502 LDLR-008 11089463-11100578 retained_intron
  ENST00000560628 LDLR-014 11127547-11133521 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000252444ENST00000535915ENST00000557958ENST00000558013ENST00000558518
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000252444 N/A N/A 2.681±0.00 3.675±0.24 1.809±0.00 N/A 2.691±0.00 1.118±0.00 N/A N/A 33.089±16.03 5.553±0.00 1.559±0.45
ENST00000535915 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.023±0.00 11.972±0.00 N/A
ENST00000557958 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.411±0.00 N/A N/A N/A
ENST00000558013 3.217±0.00 9.655±0.00 4.507±0.00 N/A 3.635±0.00 N/A N/A 1.395±0.00 N/A 0.294±0.00 28.361±0.00 N/A N/A
ENST00000558518 N/A N/A 1.068±0.00 6.473±0.00 3.246±0.00 0.948±0.00 1.619±0.00 1.517±0.00 7.944±0.00 N/A 9.355±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00058P CIL_00058P_0003 CGP 19:10961001-11133816
CIL_000169 CIL_000169_0001 CGP 19:11089362-11155808

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001523 TAS retinoid metabolic process
GO:0001948 IPI glycoprotein binding
GO:0005041 IDA low-density lipoprotein receptor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005764 IDA lysosome
GO:0005768 IEA endosome
GO:0005769 IDA early endosome
GO:0005770 IDA late endosome
GO:0005794 IDA Golgi apparatus
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005905 IDA coated pit
GO:0006629 TAS lipid metabolic process
GO:0006897 TAS endocytosis
GO:0006898 TAS receptor-mediated endocytosis
GO:0007603 TAS phototransduction, visible light
GO:0008203 IEA cholesterol metabolic process
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0010008 TAS endosome membrane
GO:0010867 ISS positive regulation of triglyceride biosynthetic process
GO:0010899 ISS regulation of phosphatidylcholine catabolic process
GO:0015914 ISS phospholipid transport
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016032 IEA viral process
GO:0030169 IEA low-density lipoprotein particle binding
GO:0030229 IDA very-low-density lipoprotein particle receptor activity
GO:0030299 IMP intestinal cholesterol absorption
GO:0030301 IMP cholesterol transport
GO:0030669 TAS clathrin-coated endocytic vesicle membrane
GO:0034362 IEA low-density lipoprotein particle
GO:0034383 IMP low-density lipoprotein particle clearance
GO:0042157 TAS lipoprotein metabolic process
GO:0042159 IEA lipoprotein catabolic process
GO:0042632 IMP cholesterol homeostasis
GO:0043235 IDA receptor complex
GO:0044281 TAS small molecule metabolic process
GO:0070508 ISS cholesterol import
GO:2000188 IEA regulation of cholesterol homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000029476 ldlr low density lipoprotein receptor protein_coding Danio_rerio
ENSDARG00000089730 low density lipoprotein receptor protein_coding Danio_rerio
ENSMUSG00000032193 Ldlr low density lipoprotein receptor protein_coding Mus_musculus

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