C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: actinin, alpha 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000130402 ACTN4 9606 + 19:38647649-38731583 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000252699 ACTN4-001 38647670-38731583 protein_coding
  ENST00000390009 ACTN4-010 38647738-38729447 protein_coding
  ENST00000424234 ACTN4-201 38647746-38729432 protein_coding
  ENST00000440400 ACTN4-004 38724157-38731583 protein_coding
  ENST00000477174 ACTN4-006 38728145-38729421 processed_transcript
  ENST00000489451 ACTN4-003 38710833-38717117 processed_transcript
  ENST00000495553 ACTN4-002 38648193-38709423 processed_transcript
  ENST00000497637 ACTN4-005 38727856-38729820 processed_transcript
  ENST00000586538 ACTN4-012 38708142-38717316 protein_coding
  ENST00000588618 ACTN4-007 38647649-38721878 retained_intron
  ENST00000589528 ACTN4-013 38647738-38730144 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000252699ENST00000390009ENST00000424234ENST00000495553ENST00000497637ENST00000588618
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000252699 55.833±0.00 31.067±0.00 3.745±0.00 8.997±0.00 19.343±13.93 19.435±13.36 7.669±0.00 33.503±0.00 10.326±0.00 N/A 6.824±0.00 23.425±18.60 N/A 22.492±0.00
ENST00000390009 117.425±0.00 63.923±0.00 7.549±0.00 22.725±19.07 86.378±0.00 67.955±0.00 21.582±0.00 53.844±46.83 20.525±0.00 N/A 14.307±11.26 106.978±81.64 66.044±0.00 22.489±10.40
ENST00000424234 N/A N/A 13.513±0.00 6.477±0.00 26.747±0.00 35.086±0.00 N/A 8.403±0.00 18.466±0.00 16.709±0.00 9.405±0.00 21.472±0.00 N/A 42.621±0.00
ENST00000495553 278.041±0.00 143.952±0.00 24.230±0.00 107.511±0.00 150.354±0.00 N/A N/A N/A N/A N/A 31.640±0.00 N/A N/A 53.979±36.21
ENST00000497637 236.012±0.00 114.971±0.00 N/A N/A 144.211±0.00 138.564±0.00 N/A 161.590±0.00 38.377±0.00 N/A N/A 179.695±0.00 N/A 90.159±0.00
ENST00000588618 107.171±0.00 N/A 14.450±0.00 6.221±0.00 30.720±0.00 45.535±10.97 10.492±6.06 10.790±0.00 20.500±0.00 17.948±0.00 5.662±0.00 140.798±110.38 196.744±0.00 14.943±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001725 IEA stress fiber
GO:0001882 IDA nucleoside binding
GO:0002576 TAS platelet degranulation
GO:0003779 TAS actin binding
GO:0005178 TAS integrin binding
GO:0005509 IEA calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005911 IEA cell-cell junction
GO:0005925 IDA focal adhesion
GO:0007596 TAS blood coagulation
GO:0015031 IEA protein transport
GO:0030018 IEA Z disc
GO:0030168 TAS platelet activation
GO:0030529 IDA ribonucleoprotein complex
GO:0030863 IEA cortical cytoskeleton
GO:0031093 TAS platelet alpha granule lumen
GO:0031143 TAS pseudopodium
GO:0032403 IEA protein complex binding
GO:0032417 NAS positive regulation of sodium:proton antiporter activity
GO:0042803 TAS protein homodimerization activity
GO:0042981 NAS regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043234 IDA protein complex
GO:0044822 IDA poly(A) RNA binding
GO:0047485 IEA protein N-terminus binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048549 IEA positive regulation of pinocytosis
GO:0051015 IDA actin filament binding
GO:0051017 IEA actin filament bundle assembly
GO:0051271 IEA negative regulation of cellular component movement
GO:0051272 IMP positive regulation of cellular component movement
GO:0051764 IEA actin crosslink formation
GO:0070062 IDA extracellular vesicular exosome
GO:0070830 IEA tight junction assembly
GO:1902396 IEA protein localization to tight junction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025364 ACTN4 (1 of 3) actinin, alpha 4 protein_coding Danio_rerio
ENSDARG00000089776 ACTN4 (2 of 3) actinin, alpha 4 protein_coding Danio_rerio
ENSMUSG00000054808 Actn4 actinin alpha 4 protein_coding Mus_musculus

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