C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: topoisomerase (DNA) II alpha 170kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131747 TOP2A 9606 - 17:40388516-40417950 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000423485 TOP2A-001 40388516-40417950 protein_coding
  ENST00000577541 TOP2A-006 40388526-40389602 protein_coding
  ENST00000577706 TOP2A-004 40396383-40399261 retained_intron
  ENST00000578412 TOP2A-005 40389562-40392101 retained_intron
  ENST00000581055 TOP2A-003 40413480-40417705 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000423485ENST00000577541ENST00000578412ENST00000581055
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000423485 0.315±0.00 0.030±0.00 0.022±0.01 2.890±0.00 2.967±2.79 0.227±0.00 0.088±0.00 N/A 1.105±0.00 13.719±12.54 10.563±10.58 18.287±6.74
ENST00000577541 N/A N/A N/A N/A N/A N/A 0.187±0.00 0.351±0.00 N/A N/A N/A N/A
ENST00000578412 N/A N/A 0.049±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000581055 N/A 0.059±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007HC CIL_0007HC_0001 CGP 17:40362931-40417950
CIL_0005R1 CIL_0005R1_0001 CGP 17:40388516-40457731

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000228 IDA nuclear chromosome
GO:0000278 TAS mitotic cell cycle
GO:0000287 IEA:IDA magnesium ion binding
GO:0000712 IBA resolution of meiotic recombination intermediates
GO:0000793 IEA condensed chromosome
GO:0000819 IBA sister chromatid segregation
GO:0002244 IEA hematopoietic progenitor cell differentiation
GO:0003677 IEA:IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003918 IDA:IEA DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080 IPI protein kinase C binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA:IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005814 IDA centriole
GO:0006200 IEA ATP catabolic process
GO:0006265 IDA:IEA DNA topological change
GO:0006266 IDA DNA ligation
GO:0006268 IBA DNA unwinding involved in DNA replication
GO:0006312 IBA mitotic recombination
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007059 IMP chromosome segregation
GO:0008022 IPI protein C-terminus binding
GO:0008094 IDA DNA-dependent ATPase activity
GO:0008144 IDA drug binding
GO:0008301 IEA:IDA DNA binding, bending
GO:0009330 IDA DNA topoisomerase complex (ATP-hydrolyzing)
GO:0019035 NAS viral integration complex
GO:0019899 IPI enzyme binding
GO:0030261 IEA chromosome condensation
GO:0030263 IDA apoptotic chromosome condensation
GO:0040016 IEA embryonic cleavage
GO:0042803 IPI protein homodimerization activity
GO:0042826 IPI histone deacetylase binding
GO:0043065 IDA positive regulation of apoptotic process
GO:0043130 IMP ubiquitin binding
GO:0043234 IDA protein complex
GO:0044774 IBA mitotic DNA integrity checkpoint
GO:0044822 IDA poly(A) RNA binding
GO:0045070 IMP positive regulation of viral genome replication
GO:0045870 IMP positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046982 IPI protein heterodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000024488 top2a topoisomerase (DNA) II alpha protein_coding Danio_rerio
ENSMUSG00000020914 Top2a topoisomerase (DNA) II alpha protein_coding Mus_musculus

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