C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: numb homolog (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000133961 NUMB 9606 - 14:73275107-73463642 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355058 NUMB-201 73275210-73355769 protein_coding
  ENST00000356296 NUMB-006 73275216-73458519 protein_coding
  ENST00000359560 NUMB-202 73275210-73355769 protein_coding
  ENST00000535282 NUMB-203 73275210-73355769 protein_coding
  ENST00000544991 NUMB-204 73275210-73355769 protein_coding
  ENST00000553415 NUMB-014 73409976-73463642 processed_transcript
  ENST00000553997 NUMB-024 73281414-73287257 processed_transcript
  ENST00000554014 NUMB-023 73277209-73285562 retained_intron
  ENST00000554315 NUMB-005 73286193-73458546 retained_intron
  ENST00000554394 NUMB-032 73284254-73458523 protein_coding
  ENST00000554521 NUMB-011 73276549-73366920 protein_coding
  ENST00000554546 NUMB-001 73275107-73458617 protein_coding
  ENST00000554818 NUMB-021 73323130-73458286 protein_coding
  ENST00000555238 NUMB-004 73275216-73458530 protein_coding
  ENST00000555307 NUMB-022 73284254-73458283 protein_coding
  ENST00000555394 NUMB-002 73275673-73458580 protein_coding
  ENST00000555738 NUMB-013 73276549-73366920 protein_coding
  ENST00000555859 NUMB-027 73284251-73410071 protein_coding
  ENST00000555987 NUMB-026 73292787-73458577 protein_coding
  ENST00000556112 NUMB-028 73297261-73458577 retained_intron
  ENST00000556600 NUMB-019 73409150-73458571 processed_transcript
  ENST00000556700 NUMB-016 73366897-73463625 processed_transcript
  ENST00000556772 NUMB-007 73275218-73299375 protein_coding
  ENST00000556989 NUMB-008 73286225-73297876 retained_intron
  ENST00000557031 NUMB-017 73355727-73457938 processed_transcript
  ENST00000557486 NUMB-025 73282245-73287173 retained_intron
  ENST00000557577 NUMB-015 73460935-73463618 processed_transcript
  ENST00000557581 NUMB-033 73462246-73463625 retained_intron
  ENST00000557597 NUMB-003 73275216-73458522 protein_coding
  ENST00000557774 NUMB-020 73322801-73458577 retained_intron
  ENST00000559312 NUMB-010 73276549-73366920 protein_coding
  ENST00000560335 NUMB-012 73276549-73366920 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000356296ENST00000359560ENST00000535282ENST00000544991ENST00000554014ENST00000554315ENST00000554521ENST00000554546ENST00000555394ENST00000555859ENST00000556772ENST00000557597
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000356296 N/A N/A N/A N/A N/A 1.862±0.00 N/A N/A N/A 0.928±0.00 N/A N/A N/A
ENST00000359560 N/A N/A N/A 10.479±0.00 4.357±0.00 N/A 3.101±0.00 N/A 6.306±0.00 0.219±0.00 1.692±0.00 2.789±0.00 N/A
ENST00000535282 5.555±0.00 7.741±0.00 2.221±0.48 2.983±0.00 8.497±0.00 0.753±0.00 11.325±0.00 3.242±0.62 21.217±0.00 4.869±0.00 5.662±1.14 7.798±0.99 N/A
ENST00000544991 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.939±0.00 9.878±0.00 N/A
ENST00000554014 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.341±0.00 N/A N/A N/A
ENST00000554315 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.799±0.00 N/A N/A N/A
ENST00000554521 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.501±0.00 21.079±0.00 28.041±0.00
ENST00000554546 4.555±0.00 6.360±0.00 N/A 7.102±0.00 N/A N/A 2.572±0.00 3.283±0.00 N/A N/A 6.381±1.77 2.793±0.75 6.651±0.00
ENST00000555394 3.852±0.00 N/A 2.955±0.00 N/A N/A 1.867±1.32 2.829±0.00 N/A 3.933±0.00 2.348±0.00 2.482±0.00 3.161±0.18 N/A
ENST00000555859 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 17.795±0.00 N/A
ENST00000556772 N/A N/A N/A N/A 1.324±0.00 N/A N/A N/A N/A 0.283±0.00 N/A N/A N/A
ENST00000557597 N/A N/A 3.173±0.00 3.065±0.00 2.608±0.00 N/A 7.046±0.00 3.103±0.00 9.358±0.00 N/A N/A 1.948±0.00 9.881±1.20

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P0 CIL_0008P0_0001 VISTA 14:72878760-73482269
CIL_0001TR CIL_0001TR_0001 CGP 14:73237497-73463642

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005769 IEA early endosome
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0007219 TAS Notch signaling pathway
GO:0007399 IEA nervous system development
GO:0007405 IEA neuroblast proliferation
GO:0007409 IEA axonogenesis
GO:0007411 TAS axon guidance
GO:0008013 IEA beta-catenin binding
GO:0016323 IEA basolateral plasma membrane
GO:0019897 IEA extrinsic component of plasma membrane
GO:0021670 ISS lateral ventricle development
GO:0021849 ISS neuroblast division in subventricular zone
GO:0030136 IDA clathrin-coated vesicle
GO:0030335 IGI positive regulation of cell migration
GO:0030862 IEA positive regulation of polarized epithelial cell differentiation
GO:0030900 IEA forebrain development
GO:0034332 IEA adherens junction organization
GO:0045177 IEA apical part of cell
GO:0045294 IEA alpha-catenin binding
GO:0045296 IEA cadherin binding
GO:0045746 IEA negative regulation of Notch signaling pathway
GO:0050769 ISS positive regulation of neurogenesis
GO:0060487 IEA lung epithelial cell differentiation
GO:1903077 IMP negative regulation of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027279 numb numb homolog (Drosophila) protein_coding Danio_rerio
ENSMUSG00000021224 Numb numb gene homolog (Drosophila) protein_coding Mus_musculus

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