C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: numb gene homolog (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021224 Numb 10090 - 12:83794034-83921934 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021647 Numb-004 83795439-83842343 protein_coding
  ENSMUST00000085215 Numb-005 83794071-83921844 nonsense_mediated_decay
  ENSMUST00000110298 Numb-007 83794036-83876810 nonsense_mediated_decay
  ENSMUST00000117217 Numb-001 83794034-83921934 protein_coding
  ENSMUST00000125089 Numb-011 83831828-83876798 retained_intron
  ENSMUST00000126943 Numb-010 83811291-83921890 protein_coding
  ENSMUST00000129335 Numb-002 83795439-83842343 protein_coding
  ENSMUST00000135962 Numb-008 83808106-83921856 protein_coding
  ENSMUST00000136848 Numb-009 83808177-83921883 protein_coding
  ENSMUST00000154043 Numb-003 83795439-83842343 protein_coding
  ENSMUST00000155112 Numb-006 83803946-83921867 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021647ENSMUST00000085215ENSMUST00000110298ENSMUST00000117217ENSMUST00000129335ENSMUST00000154043
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021647 11.013±1.93 25.949±2.03 7.088±1.37 4.170±0.04 19.610±3.64 15.785±5.82 6.566±0.48 5.815±1.65 8.687±2.90 51.833±12.79 1.591±0.36 25.808±9.03 24.363±1.77 N/A
ENSMUST00000085215 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.961±0.00 7.856±2.32 N/A
ENSMUST00000110298 N/A N/A N/A 3.975±0.00 2.624±0.31 4.615±0.26 N/A 3.913±1.13 2.634±0.91 6.884±0.22 N/A 5.929±0.00 7.653±1.29 1.954±0.00
ENSMUST00000117217 5.968±1.29 5.217±1.03 11.297±2.98 4.364±1.99 8.934±0.23 6.457±0.52 3.749±0.89 5.420±1.48 5.358±1.26 15.174±3.98 2.568±0.39 6.853±2.44 12.709±5.18 2.291±0.27
ENSMUST00000129335 N/A N/A N/A N/A N/A 18.847±6.53 N/A N/A N/A N/A N/A 7.220±0.72 N/A N/A
ENSMUST00000154043 3.132±0.00 N/A N/A 2.415±0.00 N/A 25.523±9.79 N/A 13.072±4.30 5.606±1.10 N/A N/A 7.981±2.03 8.316±2.59 7.376±0.94

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P0 CIL_0008P0_0002 VISTA 12:83418739-84022790
CIL_0001TR CIL_0001TR_0002 CGP 12:83763634-83921934

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005769 IDA early endosome
GO:0005886 TAS plasma membrane
GO:0005925 IEA focal adhesion
GO:0007399 IMP nervous system development
GO:0007405 IGI neuroblast proliferation
GO:0007409 IDA axonogenesis
GO:0008013 IPI beta-catenin binding
GO:0016323 IDA basolateral plasma membrane
GO:0019897 IDA extrinsic component of plasma membrane
GO:0021670 IMP lateral ventricle development
GO:0021849 IMP neuroblast division in subventricular zone
GO:0030136 IEA clathrin-coated vesicle
GO:0030335 IEA positive regulation of cell migration
GO:0030862 IMP positive regulation of polarized epithelial cell differentiation
GO:0030900 IMP forebrain development
GO:0034332 IGI adherens junction organization
GO:0045177 IDA apical part of cell
GO:0045294 IPI alpha-catenin binding
GO:0045296 IPI cadherin binding
GO:0045746 IMP negative regulation of Notch signaling pathway
GO:0050769 IMP positive regulation of neurogenesis
GO:0060487 IMP lung epithelial cell differentiation
GO:1903077 IEA negative regulation of protein localization to plasma membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027279 numb numb homolog (Drosophila) protein_coding Danio_rerio
ENSG00000133961 NUMB numb homolog (Drosophila) protein_coding Homo_sapiens

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