C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho-associated, coiled-coil containing protein kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134318 ROCK2 9606 - 2:11179761-11348330 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261535 ROCK2-008 11215360-11344141 nonsense_mediated_decay
  ENST00000315872 ROCK2-001 11179761-11344585 protein_coding
  ENST00000401753 ROCK2-006 11183331-11234670 protein_coding
  ENST00000431087 ROCK2-007 11221327-11287737 protein_coding
  ENST00000460262 ROCK2-004 11193910-11195116 retained_intron
  ENST00000462366 ROCK2-005 11235884-11348330 processed_transcript
  ENST00000484951 ROCK2-002 11217776-11221340 retained_intron
  ENST00000493096 ROCK2-003 11192676-11195210 retained_intron
  ENST00000616279 ROCK2-201 11181652-11344585 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000315872ENST00000401753ENST00000616279
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000315872 12.035±0.00 7.447±0.00 2.482±0.00 3.690±2.10 7.399±0.00 7.449±1.01 2.979±1.73 4.047±1.95 8.160±6.23 7.945±0.00 4.327±0.00 5.828±2.94 4.869±3.69 6.442±2.98
ENST00000401753 N/A N/A 0.876±0.00 N/A 3.219±0.00 2.861±0.00 N/A 2.303±0.00 N/A 2.215±0.00 2.945±0.00 4.473±0.00 6.018±0.00 3.724±0.00
ENST00000616279 3.237±0.00 N/A N/A 1.823±0.54 4.773±0.00 N/A 3.616±0.00 1.486±0.00 4.202±0.00 3.578±0.00 2.702±0.74 2.423±0.74 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00001X CIL_00001X_0002 CGP 2:11155198-11348330

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0000910 NAS cytokinesis
GO:0001843 IEA neural tube closure
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005198 NAS structural molecule activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0006939 TAS smooth muscle contraction
GO:0007411 TAS axon guidance
GO:0008625 IEA extrinsic apoptotic signaling pathway via death domain receptors
GO:0010825 IEA positive regulation of centrosome duplication
GO:0016525 IMP negative regulation of angiogenesis
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017048 IEA Rho GTPase binding
GO:0030036 IEA actin cytoskeleton organization
GO:0030155 TAS regulation of cell adhesion
GO:0031616 IEA spindle pole centrosome
GO:0032956 TAS regulation of actin cytoskeleton organization
GO:0035556 IEA intracellular signal transduction
GO:0036464 IDA cytoplasmic ribonucleoprotein granule
GO:0042752 ISS regulation of circadian rhythm
GO:0044822 IDA poly(A) RNA binding
GO:0045616 IMP regulation of keratinocyte differentiation
GO:0046872 IEA metal ion binding
GO:0048511 IEA rhythmic process
GO:0048813 IEA dendrite morphogenesis
GO:0051298 IMP centrosome duplication
GO:0051492 TAS regulation of stress fiber assembly
GO:0051893 TAS regulation of focal adhesion assembly
GO:2000114 TAS regulation of establishment of cell polarity
GO:2000145 TAS regulation of cell motility

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004877 rock2b rho-associated, coiled-coil containing protein kinase 2b protein_coding Danio_rerio
ENSDARG00000017500 rock2a rho-associated, coiled-coil containing protein kinase 2a protein_coding Danio_rerio
ENSDARG00000086649 ROCK2 (3 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSDARG00000087746 ROCK2 (4 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSDARG00000088086 ROCK2 (5 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSDARG00000088333 ROCK2 (6 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSDARG00000088620 ROCK2 (7 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSDARG00000089492 ROCK2 (8 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSDARG00000090999 ROCK2 (9 of 9) Rho-associated, coiled-coil containing protein kinase 2 protein_coding Danio_rerio
ENSMUSG00000020580 Rock2 Rho-associated coiled-coil containing protein kinase 2 protein_coding Mus_musculus

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