C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: clock circadian regulator
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134852 CLOCK 9606 - 4:55427903-55547138 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309964 CLOCK-005 55427903-55510027 protein_coding
  ENST00000381322 CLOCK-002 55434823-55545932 protein_coding
  ENST00000435527 CLOCK-010 55463698-55546546 protein_coding
  ENST00000479384 CLOCK-004 55442278-55443755 retained_intron
  ENST00000506747 CLOCK-007 55453760-55510066 retained_intron
  ENST00000506923 CLOCK-011 55478847-55546881 processed_transcript
  ENST00000508049 CLOCK-012 55470744-55479060 retained_intron
  ENST00000509151 CLOCK-009 55482773-55546655 processed_transcript
  ENST00000511124 CLOCK-006 55432476-55449426 retained_intron
  ENST00000513033 CLOCK-008 55486394-55546646 processed_transcript
  ENST00000513440 CLOCK-001 55435022-55547138 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309964ENST00000381322ENST00000513440
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309964 3.949±0.00 3.253±0.00 N/A 5.580±1.63 1.770±0.26 1.238±0.02 2.631±1.71 3.590±0.00 1.876±1.35 2.346±0.74 0.587±0.00 3.866±1.08 1.286±0.16 8.918±2.49
ENST00000381322 N/A N/A 1.840±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000513440 N/A N/A N/A N/A N/A 2.409±0.00 1.612±0.00 N/A N/A N/A 1.354±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00025I CIL_00025I_0001 CGP 4:55346109-55453397
CIL_00025L CIL_00025L_0001 CGP 4:55395957-55547138
CIL_00025K CIL_00025K_0001 CGP 4:55427903-55592212

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IMP DNA damage checkpoint
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 ISS RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001047 ISS core promoter binding
GO:0001190 ISS RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0004402 IMP histone acetyltransferase activity
GO:0004871 IEA signal transducer activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005667 IPI transcription factor complex
GO:0005694 IDA chromosome
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006325 TAS chromatin organization
GO:0006355 ISS:IEA regulation of transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0007165 IEA signal transduction
GO:0007283 ISS spermatogenesis
GO:0007623 TAS circadian rhythm
GO:0009648 TAS photoperiodism
GO:0016573 IEA histone acetylation
GO:0031490 ISS chromatin DNA binding
GO:0032922 ISS circadian regulation of gene expression
GO:0033391 ISS chromatoid body
GO:0042634 IMP regulation of hair cycle
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043565 ISS sequence-specific DNA binding
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046983 IEA protein dimerization activity
GO:0050729 IEA positive regulation of inflammatory response
GO:0050796 ISS regulation of insulin secretion
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051775 IDA response to redox state
GO:0070888 IDA E-box binding
GO:0071479 IDA cellular response to ionizing radiation
GO:2000074 ISS regulation of type B pancreatic cell development
GO:2000323 ISS negative regulation of glucocorticoid receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000003631 clock3 clock homolog 3 (mouse) protein_coding Danio_rerio
ENSDARG00000011703 clock clock protein_coding Danio_rerio
ENSMUSG00000029238 Clock circadian locomotor output cycles kaput protein_coding Mus_musculus

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