C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: T-box 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135111 TBX3 9606 - 12:114670254-114684164 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000257566 TBX3-002 114670255-114683590 protein_coding
  ENST00000349155 TBX3-001 114670254-114684164 protein_coding
  ENST00000548503 TBX3-005 114677592-114679933 retained_intron
  ENST00000552054 TBX3-003 114679956-114683434 retained_intron
  ENST00000613550 TBX3-201 114671841-114683461 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257566ENST00000349155ENST00000613550
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257566 1.608±0.00 2.100±0.00 N/A 0.331±0.00 3.333±0.00 N/A 1.352±0.00 0.674±0.00 2.630±0.00 0.762±0.00 2.130±0.00 2.317±1.47 7.643±0.95 1.889±1.75
ENST00000349155 9.186±0.00 3.279±0.00 0.821±0.00 0.308±0.10 3.617±2.70 4.261±0.00 1.748±1.17 4.668±2.13 4.627±1.79 8.492±5.42 3.447±0.00 6.226±4.92 13.077±0.25 2.638±2.03
ENST00000613550 N/A N/A N/A 0.267±0.00 N/A N/A 0.251±0.00 N/A N/A 6.408±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00095S CIL_00095S_0001 VISTA 12:114119731-114721669
CIL_00092A CIL_00092A_0001 VISTA 12:114147407-114748589
CIL_0008K6 CIL_0008K6_0001 VISTA 12:114385728-114986369
CIL_0008K7 CIL_0008K7_0001 VISTA 12:114386589-114987495

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001085 ISS RNA polymerase II transcription factor binding
GO:0001102 ISS RNA polymerase II activating transcription factor binding
GO:0001501 IMP skeletal system development
GO:0001568 IEA blood vessel development
GO:0001701 IEA in utero embryonic development
GO:0001947 IEA heart looping
GO:0003007 IEA heart morphogenesis
GO:0003151 IEA outflow tract morphogenesis
GO:0003167 IEA atrioventricular bundle cell differentiation
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0007569 IDA cell aging
GO:0008284 IDA positive regulation of cell proliferation
GO:0008595 IMP anterior/posterior axis specification, embryo
GO:0009887 IDA organ morphogenesis
GO:0010159 IEA specification of organ position
GO:0019827 IEA stem cell maintenance
GO:0021761 IEA limbic system development
GO:0030539 IMP male genitalia development
GO:0030540 IMP female genitalia development
GO:0030857 IEA negative regulation of epithelial cell differentiation
GO:0030879 IMP mammary gland development
GO:0032275 IMP luteinizing hormone secretion
GO:0035108 IEA limb morphogenesis
GO:0035115 IMP embryonic forelimb morphogenesis
GO:0035136 IDA forelimb morphogenesis
GO:0042127 IEA regulation of cell proliferation
GO:0042733 IMP embryonic digit morphogenesis
GO:0043066 IDA negative regulation of apoptotic process
GO:0043565 IDA sequence-specific DNA binding
GO:0045662 IDA negative regulation of myoblast differentiation
GO:0045787 IDA positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046884 IMP follicle-stimulating hormone secretion
GO:0048332 IMP mesoderm morphogenesis
GO:0055007 IEA cardiac muscle cell differentiation
GO:0060021 IEA palate development
GO:0060412 IEA ventricular septum morphogenesis
GO:0060444 IEA branching involved in mammary gland duct morphogenesis
GO:0060596 IEA mammary placode formation
GO:0060923 IEA cardiac muscle cell fate commitment
GO:0060931 IEA sinoatrial node cell development
GO:0090398 IDA cellular senescence
GO:2000648 IEA positive regulation of stem cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002216 tbx3a T-box 3a protein_coding Danio_rerio
ENSMUSG00000018604 Tbx3 T-box 3 protein_coding Mus_musculus

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