C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: MDM2 proto-oncogene, E3 ubiquitin protein ligase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000258149 MDM2-001 ENSG00000135679 9606 + 12:68808176-68850686 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainColonHeartKidneyLiverLungMuscleOvaryTestisENST00000258149
Transcript ID Adrenal Bladder Brain Colon Heart Kidney Liver Lung Muscle Ovary Testis
ENST00000258149 1.979±0.00 1.575±0.00 1.390±0.28 1.249±0.00 1.010±0.00 2.827±0.00 1.156±0.00 1.685±0.35 1.654±0.00 1.411±0.00 1.052±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KM CIL_0002KM_0002 CGP 12:68746106-68850686

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA:IDA negative regulation of transcription from RNA polymerase II promoter
GO:0002039 IPI p53 binding
GO:0004842 IMP ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IMP cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006461 IDA protein complex assembly
GO:0006977 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089 IEA traversing start control point of mitotic cell cycle
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007268 TAS synaptic transmission
GO:0008270 IDA:IEA zinc ion binding
GO:0008284 TAS positive regulation of cell proliferation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009636 IEA response to toxic substance
GO:0009743 IEA response to carbohydrate
GO:0010039 IEA response to iron ion
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010955 IEA negative regulation of protein processing
GO:0016032 IEA viral process
GO:0016567 IDA protein ubiquitination
GO:0016604 IDA nuclear body
GO:0016874 IEA ligase activity
GO:0018205 IMP peptidyl-lysine modification
GO:0019899 IPI enzyme binding
GO:0030163 IEA protein catabolic process
GO:0030666 TAS endocytic vesicle membrane
GO:0031625 IPI ubiquitin protein ligase binding
GO:0031648 IDA protein destabilization
GO:0032026 IEA response to magnesium ion
GO:0032436 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 IDA protein localization to nucleus
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042176 IDA regulation of protein catabolic process
GO:0042220 IEA response to cocaine
GO:0042493 IEA response to drug
GO:0042787 IMP:IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042802 IPI identical protein binding
GO:0042975 IEA peroxisome proliferator activated receptor binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043154 IEA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043234 IDA protein complex
GO:0043278 IEA response to morphine
GO:0043518 IDA negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087 TAS innate immune response
GO:0045184 IDA establishment of protein localization
GO:0045202 IEA synapse
GO:0045472 IEA response to ether
GO:0045787 IEA positive regulation of cell cycle
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0046677 IEP response to antibiotic
GO:0046827 IEA positive regulation of protein export from nucleus
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048545 IEA response to steroid hormone
GO:0070301 IEA cellular response to hydrogen peroxide
GO:0071157 IEA:IDA negative regulation of cell cycle arrest
GO:0071229 IEA cellular response to acid
GO:0071236 IEA cellular response to antibiotic
GO:0071301 IEA cellular response to vitamin B1
GO:0071310 IEA cellular response to organic substance
GO:0071312 IEA cellular response to alkaloid
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071391 IEA cellular response to estrogen stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071456 IEP cellular response to hypoxia
GO:0071494 IEA cellular response to UV-C
GO:0097110 IEA scaffold protein binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000020408 Mdm2-001 protein_coding Mus_musculus 0 1206
ENSMUST00000132277 Mdm2-004 retained_intron Mus_musculus 0 405
ENSMUST00000155285 Mdm2-003 nonsense_mediated_decay Mus_musculus 0 405
ENSMUST00000105263 Mdm2-002 protein_coding Mus_musculus 2e-25 124
ENSMUST00000148966 Mpv17l-005 nonsense_mediated_decay Mus_musculus 0.00006 57
ENSMUST00000023360 Mpv17l-001 protein_coding Mus_musculus 0.00006 57
ENSMUST00000141971 Mpv17l-003 protein_coding Mus_musculus 0.00006 57
ENSMUST00000128757 Mpv17l-002 protein_coding Mus_musculus 0.00006 57
ENSMUST00000028403 Cybrd1-001 protein_coding Mus_musculus 0.0008 53

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