C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: iron-sulfur cluster assembly enzyme
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136003 ISCU 9606 + 12:108562582-108569384 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311893 ISCU-001 108562601-108569384 protein_coding
  ENST00000392807 ISCU-006 108562606-108569368 protein_coding
  ENST00000431221 ISCU-004 108562601-108569092 protein_coding
  ENST00000535405 ISCU-008 108562617-108567444 retained_intron
  ENST00000535729 ISCU-003 108562601-108568547 protein_coding
  ENST00000538193 ISCU-011 108567858-108569094 retained_intron
  ENST00000539580 ISCU-005 108562606-108569368 nonsense_mediated_decay
  ENST00000539593 ISCU-007 108562610-108567908 protein_coding
  ENST00000540154 ISCU-010 108567734-108569094 processed_transcript
  ENST00000544493 ISCU-009 108564999-108567299 retained_intron
  ENST00000545932 ISCU-002 108562582-108569341 retained_intron
  ENST00000547005 ISCU-012 108562601-108569099 protein_coding
  ENST00000552072 ISCU-013 108562601-108567566 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000311893ENST00000392807ENST00000539593ENST00000545932ENST00000547005
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000311893 43.719±0.00 50.057±0.00 20.251±0.00 68.902±4.38 35.644±13.72 42.696±31.96 117.332±84.40 56.639±44.70 26.805±4.94 44.751±23.65 66.025±34.37 66.832±42.12 85.006±7.78 67.005±0.26
ENST00000392807 N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.346±0.00 N/A N/A N/A N/A
ENST00000539593 N/A N/A N/A N/A N/A N/A N/A 3.900±0.00 N/A N/A N/A N/A N/A N/A
ENST00000545932 N/A 2.905±0.00 N/A N/A N/A 0.484±0.00 N/A N/A N/A N/A N/A 1.979±0.87 N/A N/A
ENST00000547005 27.359±0.00 27.095±0.00 N/A 55.118±0.00 32.675±0.00 23.813±0.00 N/A 36.734±0.00 N/A N/A N/A N/A 20.675±0.00 40.919±9.87

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001M7 CIL_0001M7_0001 CGP 12:108522580-108569384
CIL_0007IZ CIL_0007IZ_0002 CGP 12:108562582-108598320

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005506 TAS:IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005759 TAS mitochondrial matrix
GO:0005829 IDA cytosol
GO:0009399 TAS nitrogen fixation
GO:0016226 TAS:IEA iron-sulfur cluster assembly
GO:0032947 IDA protein complex scaffold
GO:0044281 TAS small molecule metabolic process
GO:0051536 IEA iron-sulfur cluster binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000026582 iscub iron-sulfur cluster scaffold homolog (E. coli) b protein_coding Danio_rerio
ENSDARG00000035596 ISCU (2 of 2) iron-sulfur cluster assembly enzyme protein_coding Danio_rerio
ENSMUSG00000025825 Iscu IscU iron-sulfur cluster scaffold homolog (E. coli) protein_coding Mus_musculus

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