C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK2 homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136352 NKX2-1 9606 - 14:36516392-36521149 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000354822 NKX2-1-002 36516392-36520228 protein_coding
  ENST00000498187 NKX2-1-001 36516392-36519693 protein_coding
  ENST00000518149 NKX2-1-004 36516417-36521149 protein_coding
  ENST00000522719 NKX2-1-003 36517217-36520134 protein_coding
  ENST00000546983 NKX2-1-005 36519587-36520949 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainHeartLungOvaryTestisENST00000354822ENST00000522719
Transcript ID Adrenal Brain Heart Lung Ovary Testis
ENST00000354822 0.023±0.00 0.016±0.00 0.013±0.00 16.061±8.89 0.250±0.21 0.051±0.00
ENST00000522719 N/A N/A N/A N/A N/A 0.142±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00092P CIL_00092P_0001 VISTA 14:36045096-36646731
CIL_0008XR CIL_0008XR_0001 VISTA 14:36124115-36725121
CIL_0008R1 CIL_0008R1_0001 VISTA 14:36138356-36739990
CIL_00091S CIL_00091S_0001 VISTA 14:36141957-36745155
CIL_0007TC CIL_0007TC_0001 VISTA 14:36163945-36765327
CIL_0007XY CIL_0007XY_0001 VISTA 14:36204570-36805380
CIL_0007LS CIL_0007LS_0002 UCNEbase 14:36362793-37516218
CIL_0000SP CIL_0000SP_0001 CGP 14:36516392-36582607

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 ISS core promoter binding
GO:0001764 IEA neuron migration
GO:0003677 IMP:IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 ISS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006644 IEA phospholipid metabolic process
GO:0007389 IEA pattern specification process
GO:0007411 IEA axon guidance
GO:0007420 IMP brain development
GO:0007492 IEA endoderm development
GO:0007626 IEA locomotory behavior
GO:0009725 IEP response to hormone
GO:0009887 IEA organ morphogenesis
GO:0010628 IDA positive regulation of gene expression
GO:0010719 IDA negative regulation of epithelial to mesenchymal transition
GO:0019899 IPI enzyme binding
GO:0021537 IEA telencephalon development
GO:0021759 IMP globus pallidus development
GO:0021766 IEA hippocampus development
GO:0021795 IEA cerebral cortex cell migration
GO:0021798 IEA forebrain dorsal/ventral pattern formation
GO:0021877 IEA forebrain neuron fate commitment
GO:0021879 IEA forebrain neuron differentiation
GO:0021892 IEA cerebral cortex GABAergic interneuron differentiation
GO:0021895 IEA cerebral cortex neuron differentiation
GO:0021983 IEA pituitary gland development
GO:0022029 IEA telencephalon cell migration
GO:0030324 IEP lung development
GO:0030336 IDA negative regulation of cell migration
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 IMP thyroid gland development
GO:0030900 IEP forebrain development
GO:0031128 IEA developmental induction
GO:0033327 IEA Leydig cell differentiation
GO:0042753 ISS positive regulation of circadian rhythm
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048511 IEA rhythmic process
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048663 IEA neuron fate commitment
GO:0048709 IEA oligodendrocyte differentiation
GO:0060430 IEA lung saccule development
GO:0060441 IEP epithelial tube branching involved in lung morphogenesis
GO:0060486 IEA Clara cell differentiation
GO:0060510 IEA Type II pneumocyte differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019835 nkx2.1b NK2 homeobox 1b protein_coding Danio_rerio
ENSMUSG00000001496 Nkx2-1 NK2 homeobox 1 protein_coding Mus_musculus

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