C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NK2 homeobox 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000001496 Nkx2-1 10090 - 12:56531958-56536908 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000001536 Nkx2-1-002 56531958-56536908 protein_coding
  ENSMUST00000178477 Nkx2-1-001 56531958-56535106 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000001536ENSMUST00000178477
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000001536 N/A N/A N/A 2.319±1.99 N/A N/A 0.069±0.04 N/A 0.024±0.00 N/A N/A N/A N/A N/A
ENSMUST00000178477 0.035±0.02 0.033±0.02 0.168±0.03 10.010±7.98 0.055±0.03 0.030±0.00 0.218±0.13 0.025±0.01 0.111±0.13 130.076±41.99 0.026±0.01 0.212±0.08 0.085±0.04 0.044±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007LS CIL_0007LS_0003 UCNEbase 12:55566857-57467023
CIL_00092P CIL_00092P_0002 VISTA 12:56086861-56688474
CIL_0008XR CIL_0008XR_0002 VISTA 12:56140796-56741827
CIL_0008R1 CIL_0008R1_0002 VISTA 12:56154748-56756277
CIL_00091S CIL_00091S_0002 VISTA 12:56158078-56760488
CIL_0007TC CIL_0007TC_0002 VISTA 12:56181967-56783344
CIL_0007XY CIL_0007XY_0002 VISTA 12:56220183-56821029
CIL_0000SP CIL_0000SP_0002 CGP 12:56531958-56613284

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 IDA core promoter binding
GO:0001764 IMP neuron migration
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 ISS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006644 IGI phospholipid metabolic process
GO:0007389 IGI pattern specification process
GO:0007411 IMP axon guidance
GO:0007420 IGI brain development
GO:0007492 IMP endoderm development
GO:0007626 IMP locomotory behavior
GO:0009725 IEA response to hormone
GO:0009887 IMP organ morphogenesis
GO:0010628 IEA positive regulation of gene expression
GO:0010719 IEA negative regulation of epithelial to mesenchymal transition
GO:0019899 IEA enzyme binding
GO:0021537 IMP telencephalon development
GO:0021759 IMP globus pallidus development
GO:0021766 IMP hippocampus development
GO:0021795 IMP cerebral cortex cell migration
GO:0021798 IMP forebrain dorsal/ventral pattern formation
GO:0021877 IGI forebrain neuron fate commitment
GO:0021879 IMP forebrain neuron differentiation
GO:0021892 IMP cerebral cortex GABAergic interneuron differentiation
GO:0021895 IGI cerebral cortex neuron differentiation
GO:0021983 IMP pituitary gland development
GO:0022029 IMP telencephalon cell migration
GO:0030324 IMP lung development
GO:0030336 IEA negative regulation of cell migration
GO:0030512 IEA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 IMP thyroid gland development
GO:0030900 IEA forebrain development
GO:0031128 IMP developmental induction
GO:0033327 IMP Leydig cell differentiation
GO:0042753 IMP positive regulation of circadian rhythm
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IGI positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048511 IEA rhythmic process
GO:0048646 IMP anatomical structure formation involved in morphogenesis
GO:0048663 IMP neuron fate commitment
GO:0048709 IGI oligodendrocyte differentiation
GO:0060430 IGI lung saccule development
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0060486 IGI Clara cell differentiation
GO:0060510 IGI Type II pneumocyte differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019835 nkx2.1b NK2 homeobox 1b protein_coding Danio_rerio
ENSG00000136352 NKX2-1 NK2 homeobox 1 protein_coding Homo_sapiens

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