C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: NK2 homeobox 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000354822 NKX2-1-002 ENSG00000136352 9606 - 14:36516392-36520228 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainHeartLungOvaryTestisENST00000354822
Transcript ID Adrenal Brain Heart Lung Ovary Testis
ENST00000354822 0.023±0.00 0.016±0.00 0.013±0.00 16.061±8.89 0.250±0.21 0.051±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00092P CIL_00092P_0001 VISTA 14:36045096-36646731
CIL_0008XR CIL_0008XR_0001 VISTA 14:36124115-36725121
CIL_0008R1 CIL_0008R1_0001 VISTA 14:36138356-36739990
CIL_00091S CIL_00091S_0001 VISTA 14:36141957-36745155
CIL_0007TC CIL_0007TC_0001 VISTA 14:36163945-36765327
CIL_0007XY CIL_0007XY_0001 VISTA 14:36204570-36805380
CIL_0007LS CIL_0007LS_0002 UCNEbase 14:36362793-37516218
CIL_0000SP CIL_0000SP_0001 CGP 14:36516392-36582607

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001047 ISS core promoter binding
GO:0001764 IEA neuron migration
GO:0003677 IMP:IEA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 ISS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006644 IEA phospholipid metabolic process
GO:0007389 IEA pattern specification process
GO:0007411 IEA axon guidance
GO:0007420 IMP brain development
GO:0007492 IEA endoderm development
GO:0007626 IEA locomotory behavior
GO:0009725 IEP response to hormone
GO:0009887 IEA organ morphogenesis
GO:0010628 IDA positive regulation of gene expression
GO:0010719 IDA negative regulation of epithelial to mesenchymal transition
GO:0019899 IPI enzyme binding
GO:0021537 IEA telencephalon development
GO:0021759 IMP globus pallidus development
GO:0021766 IEA hippocampus development
GO:0021795 IEA cerebral cortex cell migration
GO:0021798 IEA forebrain dorsal/ventral pattern formation
GO:0021877 IEA forebrain neuron fate commitment
GO:0021879 IEA forebrain neuron differentiation
GO:0021892 IEA cerebral cortex GABAergic interneuron differentiation
GO:0021895 IEA cerebral cortex neuron differentiation
GO:0021983 IEA pituitary gland development
GO:0022029 IEA telencephalon cell migration
GO:0030324 IEP lung development
GO:0030336 IDA negative regulation of cell migration
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 IMP thyroid gland development
GO:0030900 IEP forebrain development
GO:0031128 IEA developmental induction
GO:0033327 IEA Leydig cell differentiation
GO:0042753 ISS positive regulation of circadian rhythm
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048511 IEA rhythmic process
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048663 IEA neuron fate commitment
GO:0048709 IEA oligodendrocyte differentiation
GO:0060430 IEA lung saccule development
GO:0060441 IEP epithelial tube branching involved in lung morphogenesis
GO:0060486 IEA Clara cell differentiation
GO:0060510 IEA Type II pneumocyte differentiation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000001536 Nkx2-1-002 protein_coding Mus_musculus 0 1720
ENSMUST00000178477 Nkx2-1-001 protein_coding Mus_musculus 0 1720
ENSMUST00000067020 Nkx2-4-001 protein_coding Mus_musculus 0 388
ENSDART00000007829 nkx2.1a-001 protein_coding Danio_rerio 0 220
ENSMUST00000015723 Nkx2-5-001 protein_coding Mus_musculus 0 193
ENSDART00000022377 nkx2.5-001 protein_coding Danio_rerio 5e-29 134
ENSMUST00000072631 Nkx2-9-001 protein_coding Mus_musculus 2e-28 132
ENSDART00000005296 nkx2.9-001 protein_coding Danio_rerio 3e-16 92
ENSDART00000153363 protein_coding Danio_rerio 0.00000007 64

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