C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thymine-DNA glycosylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139372 TDG 9606 + 12:103965804-103988874 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000266775 TDG-003 103965845-103987192 protein_coding
  ENST00000392872 TDG-001 103965804-103988874 protein_coding
  ENST00000436021 TDG-007 103965822-103982810 protein_coding
  ENST00000536395 TDG-010 103986234-103987025 processed_transcript
  ENST00000537100 TDG-008 103965886-103983389 protein_coding
  ENST00000540956 TDG-006 103979955-103987244 nonsense_mediated_decay
  ENST00000542926 TDG-009 103979865-103987057 retained_intron
  ENST00000544060 TDG-005 103965903-103980668 retained_intron
  ENST00000544861 TDG-004 103965845-103987194 protein_coding
  ENST00000545698 TDG-002 103965842-103980473 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000392872ENST00000540956ENST00000542926ENST00000544060ENST00000544861
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000392872 0.436±0.00 N/A 1.156±0.02 1.064±0.62 1.116±0.41 1.149±0.49 4.279±0.00 1.269±0.51 1.498±0.50 0.597±0.00 8.460±4.10 5.925±1.80 1.997±1.01
ENST00000540956 N/A N/A N/A 2.342±0.00 N/A 0.689±0.00 N/A 1.747±0.00 N/A 0.602±0.00 N/A N/A N/A
ENST00000542926 N/A 0.310±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000544060 N/A 0.195±0.00 N/A N/A 0.994±0.00 N/A 0.267±0.00 N/A 1.651±0.00 N/A N/A N/A N/A
ENST00000544861 N/A N/A N/A 1.008±0.00 N/A N/A N/A N/A N/A 1.070±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000002 CIL_000002_0002 CGP 12:103950202-103988874
CIL_0002S6 CIL_0002S6_0001 CGP 12:103965804-104064183

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001104 IEA RNA polymerase II transcription cofactor activity
GO:0003684 TAS damaged DNA binding
GO:0003690 IDA double-stranded DNA binding
GO:0005080 IEA protein kinase C binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005886 IDA plasma membrane
GO:0006281 IEA DNA repair
GO:0006284 IDA base-excision repair
GO:0006285 TAS base-excision repair, AP site formation
GO:0006298 IEA mismatch repair
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008134 IEA transcription factor binding
GO:0008263 IDA pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0009790 ISS embryo development
GO:0016568 IEA chromatin modification
GO:0016605 IEA PML body
GO:0016798 IEA hydrolase activity, acting on glycosyl bonds
GO:0016799 IEA hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 IDA DNA N-glycosylase activity
GO:0019904 IEA protein domain specific binding
GO:0030983 IEA mismatched DNA binding
GO:0032091 IEA negative regulation of protein binding
GO:0032183 IEA SUMO binding
GO:0035562 IEA negative regulation of chromatin binding
GO:0040029 ISS regulation of gene expression, epigenetic
GO:0042803 IDA protein homodimerization activity
GO:0043566 ISS structure-specific DNA binding
GO:0045008 TAS depyrimidination
GO:0080111 ISS DNA demethylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013004 tdg thymine-DNA glycosylase protein_coding Danio_rerio
ENSDARG00000086450 TDG (2 of 2) thymine-DNA glycosylase protein_coding Danio_rerio
ENSMUSG00000034674 Tdg thymine DNA glycosylase protein_coding Mus_musculus

Loading