C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thymine DNA glycosylase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000034674 Tdg 10090 + 10:82629828-82650799 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000092266 Tdg-001 82629828-82650324 protein_coding
  ENSMUST00000125970 Tdg-007 82644438-82647601 retained_intron
  ENSMUST00000133227 Tdg-003 82629876-82641322 processed_transcript
  ENSMUST00000135652 Tdg-006 82644024-82644661 retained_intron
  ENSMUST00000142658 Tdg-008 82646905-82648236 retained_intron
  ENSMUST00000145370 Tdg-004 82630667-82644289 protein_coding
  ENSMUST00000148790 Tdg-005 82641162-82644305 retained_intron
  ENSMUST00000151390 Tdg-002 82629859-82650799 protein_coding
  ENSMUST00000176195 Tdg-010 82641440-82648879 nonsense_mediated_decay
  ENSMUST00000176326 Tdg-009 82644478-82649102 protein_coding
  ENSMUST00000177353 Tdg-011 82641441-82648686 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000092266ENSMUST00000133227ENSMUST00000142658ENSMUST00000151390ENSMUST00000176195ENSMUST00000176326
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000092266 2.558±0.65 N/A 9.268±0.80 20.136±12.05 4.022±1.06 2.876±1.18 2.399±0.42 2.849±0.79 6.097±5.12 3.112±0.66 4.267±0.96 4.742±2.45 11.327±3.76 1.404±0.55
ENSMUST00000133227 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.814±0.82 N/A N/A
ENSMUST00000142658 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.288±0.00 N/A N/A
ENSMUST00000151390 4.826±1.68 9.389±3.44 2.939±0.41 12.098±1.75 3.834±1.47 5.964±2.65 0.733±0.17 2.189±0.62 3.316±0.58 4.881±0.95 0.721±0.20 7.972±1.94 4.161±1.53 0.980±0.08
ENSMUST00000176195 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.227±0.00 N/A
ENSMUST00000176326 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.628±0.47 10.839±1.41 21.694±8.80 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000002 CIL_000002_0003 CGP 10:82619851-82650799
CIL_0002S6 CIL_0002S6_0002 CGP 10:82629828-82690650

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0001104 IGI RNA polymerase II transcription cofactor activity
GO:0003690 ISS double-stranded DNA binding
GO:0005080 IPI protein kinase C binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005886 IEA plasma membrane
GO:0006281 IEA DNA repair
GO:0006284 IDA base-excision repair
GO:0006298 ISS mismatch repair
GO:0006366 IGI transcription from RNA polymerase II promoter
GO:0008134 IEA transcription factor binding
GO:0008263 IEA pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0009790 IMP embryo development
GO:0016568 IEA chromatin modification
GO:0016605 IDA PML body
GO:0016799 IEA hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 IDA DNA N-glycosylase activity
GO:0019904 IEA protein domain specific binding
GO:0030983 ISS mismatched DNA binding
GO:0032091 IDA negative regulation of protein binding
GO:0032183 IPI SUMO binding
GO:0035562 IDA negative regulation of chromatin binding
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042803 ISS protein homodimerization activity
GO:0043566 IDA structure-specific DNA binding
GO:0080111 IMP DNA demethylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013004 tdg thymine-DNA glycosylase protein_coding Danio_rerio
ENSDARG00000086450 TDG (2 of 2) thymine-DNA glycosylase protein_coding Danio_rerio
ENSG00000139372 TDG thymine-DNA glycosylase protein_coding Homo_sapiens

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