C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin-like growth factor 1 receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140443 IGF1R 9606 + 15:98648971-98964530 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268035 IGF1R-001 98648971-98964530 protein_coding
  ENST00000557873 IGF1R-012 98873719-98896889 processed_transcript
  ENST00000557938 IGF1R-014 98734712-98899546 processed_transcript
  ENST00000558355 IGF1R-017 98707831-98891619 protein_coding
  ENST00000558751 IGF1R-005 98952795-98957292 processed_transcript
  ENST00000558762 IGF1R-002 98649044-98964529 protein_coding
  ENST00000558898 IGF1R-011 98890341-98911398 protein_coding
  ENST00000558947 IGF1R-009 98897286-98899576 processed_transcript
  ENST00000559582 IGF1R-008 98900610-98913114 processed_transcript
  ENST00000559925 IGF1R-003 98649582-98916955 retained_intron
  ENST00000560144 IGF1R-016 98913176-98922242 nonsense_mediated_decay
  ENST00000560186 IGF1R-015 98820866-98896919 processed_transcript
  ENST00000560277 IGF1R-013 98820884-98896849 processed_transcript
  ENST00000560343 IGF1R-006 98923782-98924636 retained_intron
  ENST00000560432 IGF1R-010 98890542-98896886 processed_transcript
  ENST00000560972 IGF1R-004 98924600-98935366 protein_coding
  ENST00000561049 IGF1R-007 98916485-98923881 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000268035ENST00000558762ENST00000558898ENST00000559925ENST00000560144
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000268035 3.709±0.00 N/A 4.980±0.00 2.196±0.00 1.820±0.00 1.680±0.00 1.739±0.00 2.908±0.00 N/A 2.430±0.72 2.136±0.00 3.845±0.00 0.964±0.08 2.291±0.00
ENST00000558762 N/A 1.657±0.00 N/A 1.940±0.00 0.793±0.00 1.695±0.00 0.677±0.19 N/A 1.519±1.30 N/A 1.338±0.00 1.398±0.11 1.663±1.35 2.544±0.00
ENST00000558898 N/A N/A N/A N/A N/A N/A N/A 1.406±0.00 N/A N/A N/A N/A N/A N/A
ENST00000559925 N/A N/A N/A N/A 3.978±0.00 N/A 0.797±0.00 N/A 3.552±0.00 N/A N/A N/A N/A N/A
ENST00000560144 N/A N/A N/A N/A N/A N/A N/A 2.317±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008TF CIL_0008TF_0001 VISTA 15:98414511-99018999
CIL_0009CO CIL_0009CO_0001 VISTA 15:98550452-99154111
CIL_0000GM CIL_0000GM_0001 CGP 15:98648971-99007795

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001965 IEA G-protein alpha-subunit binding
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005010 IDA insulin-like growth factor-activated receptor activity
GO:0005158 IDA insulin receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005520 IDA insulin-like growth factor binding
GO:0005524 IEA ATP binding
GO:0005886 TAS plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0005901 IEA caveola
GO:0006468 IEA protein phosphorylation
GO:0006955 IMP immune response
GO:0007165 TAS signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007409 IEA axonogenesis
GO:0007420 IEA brain development
GO:0008284 TAS positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008544 IEA epidermis development
GO:0009887 IEA organ morphogenesis
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0014065 IC phosphatidylinositol 3-kinase signaling
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030010 IEA establishment of cell polarity
GO:0030238 IEA male sex determination
GO:0030335 IMP positive regulation of cell migration
GO:0030879 IEA mammary gland development
GO:0031017 IEA exocrine pancreas development
GO:0031175 IEA neuron projection development
GO:0031994 IPI insulin-like growth factor I binding
GO:0032467 IEA positive regulation of cytokinesis
GO:0033197 IEA response to vitamin E
GO:0038083 IMP peptidyl-tyrosine autophosphorylation
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043066 IDA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043235 IDA receptor complex
GO:0043409 IEA negative regulation of MAPK cascade
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043548 IPI:IEA phosphatidylinositol 3-kinase binding
GO:0043559 IPI insulin binding
GO:0043560 IPI:IEA insulin receptor substrate binding
GO:0045740 IMP positive regulation of DNA replication
GO:0045840 IEA positive regulation of mitosis
GO:0046328 IDA regulation of JNK cascade
GO:0046777 IDA:IEA protein autophosphorylation
GO:0048009 IDA insulin-like growth factor receptor signaling pathway
GO:0048015 IDA phosphatidylinositol-mediated signaling
GO:0051054 IEA positive regulation of DNA metabolic process
GO:0051262 IDA protein tetramerization
GO:0051291 IEA protein heterooligomerization
GO:0051389 IDA inactivation of MAPKK activity
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051898 IEA negative regulation of protein kinase B signaling
GO:0060740 IEA prostate gland epithelium morphogenesis
GO:0090031 IEA positive regulation of steroid hormone biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000027423 igf1ra insulin-like growth factor 1a receptor protein_coding Danio_rerio
ENSDARG00000034434 igf1rb insulin-like growth factor 1b receptor protein_coding Danio_rerio
ENSMUSG00000005533 Igf1r insulin-like growth factor I receptor protein_coding Mus_musculus

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