C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: insulin-like growth factor 1 receptor
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000268035 IGF1R-001 ENSG00000140443 9606 + 15:98648971-98964530 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000268035
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000268035 3.709±0.00 4.980±0.00 2.196±0.00 1.820±0.00 1.680±0.00 1.739±0.00 2.908±0.00 2.430±0.72 2.136±0.00 3.845±0.00 0.964±0.08 2.291±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008TF CIL_0008TF_0001 VISTA 15:98414511-99018999
CIL_0009CO CIL_0009CO_0001 VISTA 15:98550452-99154111
CIL_0000GM CIL_0000GM_0001 CGP 15:98648971-99007795

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001965 IEA G-protein alpha-subunit binding
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005010 IDA insulin-like growth factor-activated receptor activity
GO:0005158 IDA insulin receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005520 IDA insulin-like growth factor binding
GO:0005524 IEA ATP binding
GO:0005886 TAS plasma membrane
GO:0005887 IC integral component of plasma membrane
GO:0005901 IEA caveola
GO:0006468 IEA protein phosphorylation
GO:0006955 IMP immune response
GO:0007165 TAS signal transduction
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007409 IEA axonogenesis
GO:0007420 IEA brain development
GO:0008284 TAS positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008544 IEA epidermis development
GO:0009887 IEA organ morphogenesis
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0014065 IC phosphatidylinositol 3-kinase signaling
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030010 IEA establishment of cell polarity
GO:0030238 IEA male sex determination
GO:0030335 IMP positive regulation of cell migration
GO:0030879 IEA mammary gland development
GO:0031017 IEA exocrine pancreas development
GO:0031175 IEA neuron projection development
GO:0031994 IPI insulin-like growth factor I binding
GO:0032467 IEA positive regulation of cytokinesis
GO:0033197 IEA response to vitamin E
GO:0038083 IMP peptidyl-tyrosine autophosphorylation
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043066 IDA negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043235 IDA receptor complex
GO:0043409 IEA negative regulation of MAPK cascade
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043433 IEA negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043548 IPI:IEA phosphatidylinositol 3-kinase binding
GO:0043559 IPI insulin binding
GO:0043560 IPI:IEA insulin receptor substrate binding
GO:0045740 IMP positive regulation of DNA replication
GO:0045840 IEA positive regulation of mitosis
GO:0046328 IDA regulation of JNK cascade
GO:0046777 IDA:IEA protein autophosphorylation
GO:0048009 IDA insulin-like growth factor receptor signaling pathway
GO:0048015 IDA phosphatidylinositol-mediated signaling
GO:0051054 IEA positive regulation of DNA metabolic process
GO:0051262 IDA protein tetramerization
GO:0051291 IEA protein heterooligomerization
GO:0051389 IDA inactivation of MAPKK activity
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0051898 IEA negative regulation of protein kinase B signaling
GO:0060740 IEA prostate gland epithelium morphogenesis
GO:0090031 IEA positive regulation of steroid hormone biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000005671 Igf1r-201 protein_coding Mus_musculus 0 5470
ENSDART00000046542 igf1rb-001 protein_coding Danio_rerio 0 787
ENSDART00000010189 igf1ra-001 protein_coding Danio_rerio 1e-36 161
ENSDART00000135649 igf1ra-002 processed_transcript Danio_rerio 1e-26 128

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