C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurotrophic tyrosine kinase, receptor, type 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140538 NTRK3 9606 - 15:87859751-88256768 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000317501 NTRK3-002 87977364-88256159 protein_coding
  ENST00000355254 NTRK3-201 87876757-88256731 protein_coding
  ENST00000357724 NTRK3-202 87876757-88256731 protein_coding
  ENST00000360948 NTRK3-203 87876757-88256731 protein_coding
  ENST00000394480 NTRK3-001 87859751-88256747 protein_coding
  ENST00000540489 NTRK3-204 87979345-88256731 protein_coding
  ENST00000542733 NTRK3-003 87916273-88205933 protein_coding
  ENST00000557856 NTRK3-004 87876791-88256177 protein_coding
  ENST00000557897 NTRK3-009 88072601-88126361 processed_transcript
  ENST00000558306 NTRK3-017 87979054-88127191 nonsense_mediated_decay
  ENST00000558576 NTRK3-007 87916262-87933090 protein_coding
  ENST00000558676 NTRK3-015 87926656-88256179 protein_coding
  ENST00000559067 NTRK3-013 88255906-88256768 processed_transcript
  ENST00000559188 NTRK3-005 88137461-88252622 protein_coding
  ENST00000559680 NTRK3-008 87931082-87940735 processed_transcript
  ENST00000559764 NTRK3-011 88131969-88136478 processed_transcript
  ENST00000560017 NTRK3-010 88072551-88135938 protein_coding
  ENST00000560201 NTRK3-016 87977367-87978803 processed_transcript
  ENST00000560739 NTRK3-006 88072424-88099265 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000317501ENST00000394480ENST00000540489ENST00000542733ENST00000557856ENST00000558676
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000317501 0.743±0.00 2.292±0.00 N/A 8.349±0.00 1.874±0.00 1.054±0.00 0.500±0.00 1.282±0.00 0.057±0.00 1.078±0.00 N/A 0.936±0.00 0.238±0.06 2.414±0.00
ENST00000394480 N/A N/A 0.397±0.00 1.410±0.00 0.406±0.00 0.135±0.00 0.171±0.00 0.138±0.12 0.010±0.00 0.131±0.01 N/A 0.003±0.00 0.024±0.00 0.127±0.00
ENST00000540489 N/A N/A N/A N/A 0.214±0.00 N/A N/A N/A N/A N/A 0.376±0.00 N/A N/A 1.233±0.00
ENST00000542733 N/A N/A N/A N/A N/A N/A N/A 0.146±0.00 N/A N/A N/A N/A N/A 1.069±0.00
ENST00000557856 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.146±0.00 N/A
ENST00000558676 N/A N/A N/A N/A N/A 0.191±0.00 N/A N/A 0.065±0.00 0.256±0.00 N/A N/A 0.083±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000NY CIL_0000NY_0001 CGP 15:86141996-88256768
CIL_0001AZ CIL_0001AZ_0001 CGP 15:87859751-88467419

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IDA activation of MAPK activity
GO:0001764 IEA neuron migration
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0002039 IPI p53 binding
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005030 IDA neurotrophin receptor activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005886 IEA plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007169 IDA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007623 IEA circadian rhythm
GO:0008284 IDA positive regulation of cell proliferation
GO:0010628 IDA positive regulation of gene expression
GO:0016020 IEA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019056 IEA modulation by virus of host transcription
GO:0030335 IDA positive regulation of cell migration
GO:0032148 IDA activation of protein kinase B activity
GO:0032856 IDA activation of Ras GTPase activity
GO:0033138 IDA positive regulation of peptidyl-serine phosphorylation
GO:0038179 IEA neurotrophin signaling pathway
GO:0042490 IEA mechanoreceptor differentiation
GO:0043121 TAS neurotrophin binding
GO:0043235 IDA receptor complex
GO:0045471 IEA response to ethanol
GO:0046777 IEA protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048665 IEA neuron fate specification
GO:0048678 IEA response to axon injury
GO:0048691 IEA positive regulation of axon extension involved in regeneration
GO:0048712 IEA negative regulation of astrocyte differentiation
GO:0050927 IDA positive regulation of positive chemotaxis
GO:0051412 IEA response to corticosterone
GO:0060548 IEA negative regulation of cell death
GO:0070306 IEA lens fiber cell differentiation
GO:0071300 IEA cellular response to retinoic acid
GO:0090102 IEA cochlea development
GO:2000251 IDA positive regulation of actin cytoskeleton reorganization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063035 ntrk3b neurotrophic tyrosine kinase, receptor, type 3b protein_coding Danio_rerio
ENSDARG00000077228 ntrk3a neurotrophic tyrosine kinase, receptor, type 3a protein_coding Danio_rerio
ENSMUSG00000059146 Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 protein_coding Mus_musculus

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